Y. Sun

This study shows that PEBP4 interacts with TYLCV CP to regulate apoptosis and autophagy in whiteflies, balancing virus loading and immune response.

This study identifies keratin-derived antimicrobial peptides (KAMPs) that simultaneously reduce inflammation and infection by targeting TLRs and co-receptors, offering a dual therapeutic strategy for inflammatory and infectious diseases.

This study evaluates the efficacy of Salmonella typhimurium A1-R in arresting tumor growth in a triple-negative matrix-producing breast carcinoma PDOX model.

This study finds that gut microbiome features, including increased Enterococcus and total bacterial abundance, and decreased butyrate-producing bacteria, are associated with sepsis onset and mortality.

This study determines the crystal structure of pDLA-88*001:01 and identifies its peptide-binding motif, revealing structural differences between two categories of DLA-88 alleles in dogs and their implications for antiviral immunity.

This study shows that Newcastle disease virus induces ferroptosis in tumor cells via the p53-SLC7A11-GPX4 pathway, leading to nutrient deprivation and cell death.

This study identifies the structural and molecular mechanisms of two neutralizing antibodies against FMDV, showing they disrupt virus-receptor interactions and provide prophylactic and therapeutic benefits.

This study shows Hsp70 chaperones TDP-43 in liquid-like phase, preventing its aggregation and maintaining dynamic nuclear bodies under stress.

The paper identifies a deep-sea bacterial threonine dehydratase that catalyzes cysteine desulfuration to produce hydrogen sulfide, revealing structural and functional mechanisms.

This study shows that DSS-induced colitis in mice damages colonic crypts, leading to reduced smooth muscle tension and impaired myogenic contractions.

This study reveals that the nuclear localization sequence of hnRNPA1 forms the core of amyloid fibrils and interacts with Kap{beta}2 to stabilize them, linking nucleo-cytoplasmic transport to neurodegeneration.

This study develops a high-throughput single-cell DNA library preparation method for CNV detection and applies it to identify clonal evolution in hepatocellular carcinoma recurrence.

The paper systematically investigates dynamic mechanical stimulation protocols for mesenchymal stromal cells to optimize matrix production and myofibrogenesis in 3D hydrogels.

The paper introduces REPOST, a framework predicting potential virus hosts by analyzing receptor orthologs, achieving 95.74% accuracy for SARS-CoV-2.

This study develops and tests a recombinant RBD-Fc vaccine against SARS-CoV-2, showing protection in non-human primates and mice.

This study links Prochlorococcus genome reduction to the Neoproterozoic Snowball Earth climate event, showing how extreme conditions drove metabolic adaptations.

This paper identifies and characterizes a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 receptor binding and membrane fusion, showing protective effects in mice and non-adverse effects in rhesus macaques.

The study identifies conserved and divergent ABA gene regulatory networks across Brassicaceae species, revealing how network structure influences growth control under stress.

This study shows ASIC1a contributes to cardiac ischemia-reperfusion injury and that inhibiting it protects heart function, with genetic variants linked to myocardial infarction.

This study shows that sucrose promotes tillering in rice by inhibiting strigolactone (SL) signaling, specifically by suppressing D3 and D14, which are key components of SL perception and D53 degradation.

This study shows that human ILC2 cells can be activated by TLR4 signaling through LPS, leading to cytokine production and B cell activation, distinct from classical IL-33 activation.

The paper identifies that severe COVID-19 patients lack ISG-expressing cells and have antibodies that block their production, contrasting with mild cases.

This study shows allantoin induces pruritus in CKD by activating MrgprD and TRPV1 in DRG neurons.

This study introduces a computational method to identify genetic regulators of cell identity using epigenetic data across diverse species and validates findings with CRISPR experiments.

This paper introduces a polymer gel matched to water's refractive index, enabling high-resolution imaging of living cells and organisms in thick layers.

This paper shows Brazilin inhibits alpha-synuclein fibril formation and reduces toxicity in Parkinson's disease by altering conformational equilibrium.

A potent neutralizing antibody protected against SARS-CoV-2 in an hACE2 mouse model by blocking viral receptor interaction.

This study shows hypoxia inhibits beta-2 adrenergic receptor resensitization by impairing PP2A activity via PI3Kgamma and I2PP2A phosphorylation, and beta-blockers reverse this effect.

This study shows insulin impairs β2AR function via GRK2 and PP2A inhibition, with PI3Kγ regulating PP2A to sustain β2AR phosphorylation.

The paper reports an unexpectedly high mutation rate in Thermococcus eurythermalis, challenges the hypothesis of low mutation rates in hyperthermophiles, and links mutation rate to genome size and population dynamics.