Y. Sun

This study shows that inhibiting DDX3X in breast cancer cells increases type I interferon response and enhances anti-tumor immunity by promoting antigen presentation and T cell infiltration.

The serine/threonine kinase PrkC modulates both MreB filament density and cellular growth rate by sensing lipid II in Bacillus subtilis.

This paper identifies a novel allele of the chromogen gene C from wild rice that regulates anthocyanin biosynthesis differently in indica and japonica subspecies.

This study shows that brassinosteroids increase root diameter in sugar beet by promoting parenchyma cell expansion and secondary xylem differentiation.

The paper shows that PI3K inhibition reverses single cell migration direction in electric fields but not in large cell groups, with different behavior observed in group interiors and edges.

This paper identifies two potent DHODH inhibitors with broad-spectrum antiviral activity against RNA viruses, including SARS-CoV-2, and suggests their potential clinical use.

This study shows Rbx1 and Ube2m differentially regulate Treg cell homeostasis and function, with Rbx1 deletion causing severe inflammation and Ube2m deletion causing milder issues, suggesting therapeutic potential for targeting neddylation/CRLs in immune disorders.

This study shows SARS-CoV-2 suppresses selenoprotein mRNA expression linked to ferroptosis, ER stress, and DNA synthesis, while increasing IL-6 expression in Vero cells.

This study compares the gut DNA and RNA viromes of Chinese residents and Pakistani visitors, finding ethnic origin significantly influences virome composition and diversity.

This study uses 3D printing to create vessel architectures that induce more physiologically relevant phenotypes in vascular smooth muscle cells compared to 2D cultures.

This study identifies FXR1 as a driver of cMYC translation through mRNA circularization and eIF4F recruitment in ovarian cancer, linking FXR1 amplification to poor prognosis.

This study identifies gut microbiota changes and their associations with cerebral cortex and cerebrovascular abnormalities in human mild traumatic brain injury.

The paper shows red-light promotes mutualism between begomovirus and whitefly by stabilizing βC1, which inhibits plant defenses through interference with PIFs and MYC2 transcriptional activity.

This study shows that a recombinant SARS-CoV-2 S1-Fc fusion protein induces strong neutralizing antibodies in nonhuman primates and can be produced at scale for vaccine development.

This study shows that excessive polyamine production in keratinocytes drives self-RNA sensing by dendritic cells, contributing to psoriasis inflammation.

This study characterizes the microbial composition and environmental factors in hotel rooms across continents, finding associations between fungal and bacterial diversity, quantity, and environmental characteristics.

This study identifies RNA secondary structures of the full SARS-CoV-2 genome in infected cells, revealing alternative conformations that influence frameshifting rates.

The paper studies how rat embryonic fibroblast monolayers form radial symmetry under confinement, showing that contractility and cell-cell adhesion drive this structure.

This paper introduces a nonlinear FEM framework in Matlab for analyzing and optimizing bio-inspired compliant mechanisms in medical applications, showing its accuracy through simulations and experiments.

The paper develops a dynamic EHT model to enhance contractile function and study desmosome-linked disease phenotypes in engineered heart tissues.

The paper shows that pericytes, not endothelial cells, express ACE2 in microvessels, suggesting they may be infected in COVID-19 and contribute to microvascular inflammation and hypercoagulopathy.

This study identifies a protoporphyrin derivative that inhibits entry of enveloped viruses by targeting viral lipids, showing broad antiviral activity in vitro and in vivo.

The paper determines the near-atomic structure of the SARS-CoV-2 polymerase complex and shows reduced activity and thermostability compared to SARS-CoV.

The paper identifies Linc00402 as a novel lncRNA regulating allogeneic T-cell responses through RNA-seq analysis of human T-cells post-HSCT.

The paper determines the cryo-EM structure of phosphorylated α-synuclein fibrils at Tyr39, revealing structural changes linked to Parkinson's disease pathology.

This study shows Carmofur inhibits SARS-CoV-2 main protease by covalently binding to Cys145 and occupying the S2 subsite, with an EC50 of 24.30 M in cell-based viral replication assays.

This study produces and tests an F(ab')2 fragment against SARS-CoV-2 RBD, showing potent in vitro neutralization with an EC50 of 0.07 g/ml.

This study analyzes plastome sequences from Gentianeae to show gene tree discordance and evolutionary rate heterogeneity among plastid genes, suggesting the need for more nuanced phylogenomic approaches.

The paper was withdrawn due to the authors no longer supporting some conclusions.