Z. Wu

This study shows that SARS-CoV-2 nucleocapsid protein reduces pluripotency in human iPSCs, causing them to lose differentiation ability and adopt fibroblast-like morphology.

This study shows that high concentrations of angiotensin II induce apoptosis in human iPSC-derived cardiomyocytes after long-term exposure.

This paper introduces an acoustofluidic device to create 3D neurospheroids for modeling Alzheimer's disease neuroinflammation and amyloid-β toxicity.

The paper designs novel covalent inhibitors against SARS-CoV-2 using a deep Q-learning network and fragment-based drug design, generating 47 lead compounds available in a public repository.

The paper develops an in vitro vesicle formation assay to identify proteins involved in cargo sorting and trafficking, revealing novel regulators like FAM84B and PRRC1.

This paper introduces a DNA-brick assisted centrifugation method to sort liposomes by size, enabling the study of membrane curvature effects on protein activity.

This paper develops a microfluidic platform to assemble human brain organoids and models prenatal cannabis exposure effects on early brain development.

The paper assesses changes in drifting fish egg composition and abundance in the Xijiang River after dam construction, linking these changes to environmental factors.

This study compares fast familiarity and slow recollection processes in humans and macaques using recognition memory tasks, finding comparable time courses across species.

The paper investigates correlated evolution of large DNA fragments in the 3D genome of Arabidopsis thaliana, showing that spatially interacting fragments exhibit similar polymorphism and evolutionary rates.

This study shows SHIP2 is phosphorylated by EphB2 and contributes to cell repulsion in EphB2-ephrinB1 signaling, but not in reverse signaling.

The paper introduces GLAMS, a method using glycosyltransferase labeling and mass spectrometry to identify sialylation linkages at the glycopeptide level, successfully identifying 1,236 linkage-specific sialoglycopeptides from human serum.

The paper isolates and characterizes a Rhizobium bacterium associated with the dinoflagellate Gambierdiscus balechii, showing it benefits from the association by utilizing extracellular organic matter.

This study investigates the role of ASK1/p38-mediated NLRP3 inflammasome signaling in diabetic retinopathy, showing its contribution to inflammation and aberrant retinal angiogenesis.

This study compares immune response kinetics between two chicken lines infected with Eimeria maxima, finding early cytokine responses in resistant chickens.

This study investigates how mechanical strain magnitude and rate affect bone adaptation in adult women over 12 months, finding that higher strain rates and loading doses correlate with increased bone mineral content.

This study determines the cryo-EM structure of RyR1 and uses simulations to analyze cation hydration and conduction mechanisms in the receptor.

This study identifies that BTLA and PD-1 use distinct phosphatases to differentially repress T cell signaling, highlighting mechanistic differences between two co-inhibitory receptors.

This study develops a proteomic workflow for FFPE tissues to stratify prostate cancer and DLBCL samples, identifying MPO as a prognostic marker and showing FFPE's utility for biomarker discovery.

This study uses STED nanoscopy with a new dye to visualize mitochondrial cristae dynamics in live cells at high resolution.

This study shows that APOL1-G0 protects podocytes from HIV-induced damage in mice, while APOL1-G2 does not provide similar protection.

The paper uses molecular dynamics simulations to study proton-coupled amino acid transport in GkApcT, showing that deprotonation of E115 facilitates the transition from inward-occluded to inward-open states.

The paper uses direct fluorescent glycan labeling to image N- and O-glycans on HeLa cells, revealing distinct distribution patterns of Core-1 O-glycans, N-glycans, and sialyl T antigen.

The paper identifies MISTERMINATE as a mechanism linking mitochondrial dysfunction to proteostasis failure through translational termination impairment and C-terminal extension of mitochondrial proteins.

The paper describes a modified TCA/acetone precipitation method for plant protein extraction that is faster and reduces protein degradation compared to traditional methods.

The paper presents cryo-EM structures of the human 26S proteasome in seven conformational states during polyubiquitylated protein degradation, revealing dynamic substrate-proteasome interactions and ATP hydrolysis mechanisms.

The paper examines mitochondrial chromosome presence and absence variation in Silene species, finding rapid chromosome loss and no recombination between haplotypes.

This study investigates the effect of L. reuteri on immune parameters and gut microbiota, revealing sex-specific differences in immune response and microbial composition.

This study generates transgenic pigs expressing microbial enzymes to enhance feed digestion and reduce nutrient emissions, showing improved growth and lower environmental impact.

The paper quantifies protein-membrane interactions using single-molecule force spectroscopy, showing C2 domains resist forces of 2-7 pN and have binding energies of 4-14 kBT.