Z. Yuan

This paper develops a laser-activated drug implant for controlled release in the posterior eye, showing in vitro and in vivo drug release kinetics and safety.

The paper develops a biparatopic antibody-ACE2 fusion (89C8-ACE2) that effectively blocks SARS-CoV-2 infection in vitro and neutralizes authentic virus at low nanomolar concentrations.

This study shows that immunization with SARS-CoV-2 RBD induces antibodies that neutralize both SARS-CoV-2 and SARS-CoV without causing antibody-dependent enhancement.

This study shows high cholesterol enhances SARS-CoV-2 entry and infectivity by promoting ACE2 and furin localization, contributing to COVID19 severity in elderly and obese individuals.

This study shows that protoporphyrin IX and verteporfin inhibit SARS-CoV-2 infection in vitro and in a human ACE2-expressing mouse model by blocking ACE2-S protein interaction.

This study identifies a vertically transmitted core virome in Aedes albopictus mosquitoes across developmental stages and continents, and finds a novel virus related to Yongsan bunyavirus 1.

This study identifies ACE2 orthologs from diverse species that can support SARS-CoV-2 entry, suggesting a broad host range for the virus.

This study uses human liver organoids to show SARS-CoV-2 infects cholangiocytes, disrupts bile transport, and causes liver damage, suggesting targeting viral effects on the liver could improve COVID-19 treatment.

This paper identifies YdiU as a Mn2+-dependent UMPylase in Salmonella that modulates chaperone function through UMPylation, enhancing stress resistance.

This study links cellular virological stages in chronic hepatitis B to liver fibrosis progression through spatial and functional analysis of viral and host gene expression.

The paper shows Ctf4 organizes sister replisomes and Pol alpha into a replication factory by dimerizing CMG helicase and binding one Pol-primase.

The paper compares subgenome asymmetry in artificial and natural allopolyploid genotypes, finding that variable genome components influence subgenome differences and suggest their consideration in polyploid evolution studies.

The paper reports the cryo-EM structure of the eukaryotic CMG helicase on forked DNA, revealing a 'dam-and-diversion tunnel' mechanism for DNA unwinding.

This study shows non-antibiotic pharmaceuticals can increase antibiotic resistance spread via conjugation by enhancing ROS production and cell membrane permeability.

The paper performs single-cell RNA sequencing on TNBC tumors to identify novel immune cell subsets and their associations with survival and TCR signaling.

This study identifies TIM-1 and endocytic pathways as key mediators of exosome entry and cargo delivery for IFN-α-induced antiviral activity transfer from macrophages to hepatocytes.

This study investigates how daclatasvir impairs HCV replicase assembly by disrupting NS4B-involved protein interactions and altering replicase quaternary structure.

This study identifies extracellular HBV RNAs as heterogeneous in length, present in virions and capsid-antibody-complexes in CHB patients, and capable of serving as templates for viral DNA synthesis.

This study determines the structure of the RBPJ-SHARP complex and shows that SHARP binding is essential for RBPJ's repressor function in Notch signaling.

This study shows that triclosan exposure induces antibiotic resistance in E. coli through genetic mutations and gene expression changes.