Wendy Dean

Quantifying the relationship between cell proliferation and morphology during development of the face

The paper develops an imaging pipeline to quantify 3D cellular proliferation and morphology during mouse facial development, showing their tight correlation.

MusMorph, a database of standardized mouse morphology data for morphometric meta-analyses

MusMorph provides standardized mouse morphology data for meta-analyses, including craniofacial and brain structures across developmental stages and genotypes.

Single cell multi-omics profiling reveals a hierarchical epigenetic landscape during mammalian germ layer specification

The paper uses single cell triple-omics analysis to reveal how epigenetic changes drive germ layer specification in mouse embryos, showing distinct epigenetic priming and remodeling in different lineages.

Genome-scale oscillations in DNA methylation during exit from pluripotency

The paper shows that during exit from pluripotency, coexpression of DNMT3s and TETs drives genome-scale DNA methylation oscillations, with amplitude dependent on CpG density, observed both in vitro and in vivo.

5-Formylcytosine controls nucleosome positioning through covalent histone-DNA interaction

This study shows that 5-formylcytosine (5fC) influences nucleosome positioning through covalent histone-DNA interactions in mouse embryonic stem cells.

A non-catalytic role of TET3 promotes open chromatin and enhances global transcription

This paper shows TET3 promotes open chromatin and enhances global transcription in embryonic stem cells, independent of its catalytic activity.