Jared B. Smith

Portable transcranial therapeutic ultrasound enhances targeted gene delivery for Parkinson's disease: from rodent models to non-human primates

Portable therapeutic ultrasound enhanced AAV9 delivery to the brain in mice and rhesus macaques compared to systemic injection alone.

GluK2 is a target for gene therapy in drug-resistant Temporal Lobe Epilepsy

This study demonstrates that gene therapy targeting GluK2 reduces seizures in TLE models and patient-derived slices.

Brain-wide Correspondence Between Neuronal Epigenomics and Long-Distance Projections

The paper links single-cell epigenomes and projection patterns of 33,034 mouse neurons to identify transcriptomic and epigenomic properties of projection cell types.

Epigenomic Diversity of Cortical Projection Neurons in the Mouse Brain

The paper links epigenomic properties of cortical projection neurons to their anatomical and projection patterns using single-nucleus DNA methylation sequencing in mice.

Viral manipulation of functionally distinct neurons from mice to humans

The paper identifies enhancers for targeting specific neuronal subtypes across species and demonstrates their utility in circuit manipulation.

Core and Matrix Thalamic Sub-Populations Relate to Spatio-Temporal Cortical Connectivity Gradients

The paper identifies Core and Matrix thalamic sub-populations and links them to spatio-temporal cortical connectivity gradients using fMRI and calcium-binding protein data.