Melissa Gorham

Morphoelectric Diversity and Specialization of Neuronal Cell Types in the Primate Striatum

The paper analyzes multi-modal Patch-seq data from macaque striatum to reveal morphoelectric diversity and functional specialization of neuronal cell types, highlighting primate-specific features and differences from rodents.

A whole-brain monosynaptic input connectome to neuron classes in mouse visual cortex

The paper maps brain-wide monosynaptic inputs to specific neuron classes in mouse visual cortex using an improved rabies virus tracing strategy and identifies connectivity patterns within and between visual areas.

Local Connectivity and Synaptic Dynamics in Mouse and Human Neocortex

The paper presents a synaptic physiology dataset and analysis platform to study cortical microcircuit structure and synaptic properties in mouse and human neocortex, revealing layer-dependent connectivity and subclass-specific dynamics.

Characterization of a fiber-coupled EvenField illumination system for fluorescence microscopy

The paper characterizes fiber-coupled illumination systems for fluorescence microscopy, comparing speckle reduction schemes and introducing a new design called the EvenField Illuminator.

Toward an integrated classification of neuronal cell types: morphoelectric and transcriptomic characterization of individual GABAergic cortical neurons

The paper characterizes transcriptomic and physiological properties of GABAergic cortical neurons in mice, identifying 20 interneuron met-types with consistent features across modalities.

Human cortical expansion involves diversification and specialization of supragranular intratelencephalic-projecting neurons

The paper identifies transcriptomic diversity in human supragranular neurons and links it to functional specialization and disease vulnerability.

Classification of electrophysiological and morphological types in mouse visual cortex

The paper classifies neurons in mouse visual cortex into 17 electrophysiological and 35 morphological types using unsupervised methods and links them to transcriptomic types.

Multimodal cell type correspondence by intersectional mFISH in intact tissues

The paper presents a method combining spatial transcriptomics with optogenetic mapping to resolve cell type characteristics in mouse cortex.