Tracy L. Bale

Rapid modeling of an ultra-rare epilepsy patient variant in mice by in utero prime editing

This paper describes a method to rapidly create mouse models of human epilepsy variants using in utero prime editing, enabling the study of seizures in a clinically relevant timeframe.

Single-cell genomics reveals region-specific developmental trajectories underlying neuronal diversity in the human hypothalamus

The paper uses single-cell genomics to reconstruct developmental trajectories of 170 neuronal subtypes in the human hypothalamus across development.

Colonization at birth with human CST IV cervicovaginal microbiota alters development and increases neonatal mortality in mice

The paper shows that colonization with nonoptimal human cervicovaginal microbiota in mice leads to developmental issues and increased neonatal mortality.

It’s the fiber, not the fat: Significant effects of dietary challenge on the gut microbiome

This study shows that dietary fiber, not fat, drives gut microbiota changes when comparing refined diets to chow in mice, with sex and age effects observed.

Epididymal glucocorticoid receptors promote intergenerational transmission of paternal stress

This study identifies epididymal glucocorticoid receptors as mediators of paternal stress effects on offspring through changes in extracellular vesicle miRs.