Yuri Bozzi

Developmental excitation-inhibition imbalance permanently reprograms autism-relevant social brain circuits

This study shows that a transient developmental excitation-inhibition imbalance causes lasting social brain circuit dysfunction in mice, with behavioral and transcriptional consequences.

Biological subtyping of autism via cross-species fMRI

The paper identifies hypo- and hyperconnectivity subtypes in autism using cross-species fMRI, linking them to distinct biological mechanisms in mice and humans.

Automated assessment of the mouse body-language reveals pervasive behavioral disruption in a two-hit model of psychiatric vulnerability

This paper uses automated body-language analysis to show that a dual-hit mouse model of psychiatric vulnerability exhibits distinct neurobehavioral profiles shaped by genotype and early-life adversity.

Sex-biasing influence of autism-associated Ube3a gene overdosage at connectomic, behavioral and transcriptomic levels

This study shows that Ube3a gene overdosage causes sex-biased effects on brain connectivity, behavior, and gene expression in mice, linking it to autism-related phenotypes.

Early-life scarcity adversity biases behavioral development toward a bipolar-like phenotype in mice heterozygous for CNTNAP2

This study shows that early-life adversity in Cntnap2 heterozygous mice leads to bipolar-like behaviors and synaptic changes in the amygdala.

N-acetylcysteine counteracts immune dysfunction and autistic-related behaviors in the Shank3b mouse model of Autism Spectrum Disorders

This study shows that N-acetylcysteine reduces inflammation and improves social behavior in a Shank3b mouse model of ASD.

Gene expression profiling in trigeminal ganglia from Cntnap2-/- and Shank3b-/- mouse models of autism spectrum disorder

This study examines gene expression changes in trigeminal ganglia of Shank3b and Cntnap2 mutant mice to understand tactile sensory deficits in autism.

Somatosensory processing deficits and altered cortico-hippocampal connectivity in Shank3b-/- mice

This study investigates somatosensory processing deficits in Shank3b-/- mice, finding reduced cortical and hippocampal activation and connectivity linked to hypo-responsiveness to tactile stimuli.

Proteoglycan Clusters as a Site of Coordinated, Multi-Dendritic Plasticity

The paper identifies CS6 clusters as extracellular matrix microenvironments that support coordinated multi-dendrite synaptic plasticity in response to sensory stimuli.

Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes

The paper maps brain connectivity in 16 autism mouse models to identify four subtypes of functional connectivity abnormalities linked to different etiologies.