The paper identifies LRRC57/RABIN as a presynaptic inhibitor of Rab GTPases in glutamatergic neurons, showing it regulates neurotransmitter release and prevents epileptiform activity.

bioRxiv · Sep 28, 2026 · PreprintNeuroscience

Suppression of non-canonical autophagy induces endothelial and cardiac dysfunction

Joëlle Magné, Suresh Poudel, Rona J. Strawbridge, Luigi Mari, Maria Sabater‐Lleal, Clifford S. Guy, Thomas Confer, Melissa Johnson, Mia Panlilio, Jaison John, Nicolas Denans, Pashupati Prasad Mishra, Joey Ward, Aaron Pitre, Aaron Taylor, , Douglas R. Green

This study shows that disrupting non-canonical autophagy (LANDO) impairs endothelial and cardiac function by disrupting VEGFR2 recycling and Hb- expression.

bioRxiv · Dec 18, 2025 · PreprintPhysiology

RBM39 degrader invigorates natural killer cells to eradicate neuroblastoma despite cancer cell plasticity

Shivendra Vikram Singh, Jie Fang, Hongjian Jin, Lee-Ann Van de Velde, Andrew Cortes, Jiani Chen, Sivaraman Natarajan, Evon Poon, Qiong Wu, Christopher L. Morton, Mary A. Woolard, Waise Quarni, Jacob A. Steele, Jon P. Connelly, Liusheng He, , Jun J.J. Yang

This study shows that targeting RBM39 with indisulam promotes natural killer cell activity and eradicates neuroblastoma regardless of cellular state plasticity.

Nature Communications · Sep 17, 2025Peer-reviewedCancer Biology

Conditional c-MYC activation in catecholaminergic cells drives distinct neuroendocrine tumors: neuroblastoma vs somatostatinoma

Tingting Wang, Lingling Liu, Jie Fang, Hongjian Jin, Sivaraman Natarajan, Heather Sheppard, Meifen Lu, Gregory H. Turner, Thomas Confer, Melissa D. Johnson, Jeffrey D. Steinberg, Larry Ha, Nour Yadak, Richa Jain, David J. Picketts, , Jun Yang

This study creates two mouse models with conditional c-MYC activation in specific cell types, leading to distinct neuroendocrine tumors resembling human neuroblastoma and somatostatinoma.

Cancer Research · Nov 12, 2024Peer-reviewedCancer Biology