Ian J. Deary

This study shows that DNAm GrimAge predicts disease incidence and prevalence better than other epigenetic clocks in a large cohort.

The paper develops an epigenetic CRP score to assess chronic inflammation and its link to cognitive ability, finding it more consistently associated with cognition than serum CRP across two cohorts.

This study identifies lipid biomarkers associated with brain structure but not cognitive ability in older adults using metabolomic data from the LBC1936 cohort.

The paper identifies SNPs with sex-specific effects on lung function traits using UK Biobank data, finding a significant interaction at rs7697189 near HHIP.

This study identifies traits associated with polygenic risk for depression using UK Biobank data and finds causal links between depression risk and brain structure, as well as environmental interactions.

This study examines age-related changes in PSMD across the adult lifespan using multi-cohort diffusion tensor imaging data, finding PSMD increases consistently while other metrics show different age patterns.

This study predicts promoter-anchored chromatin interactions using DNA methylation QTL data from a human cohort, finding overlaps with experimental data and associations with complex traits.

The paper investigates associations between polygenic risk scores for schizophrenia, psychotic-like experiences, and structural brain network properties in healthy UK Biobank participants.

The paper develops a DNA methylation-based risk score for cardiovascular disease and shows it predicts risk independently of traditional factors.

The paper quantifies the effect of copy number variants on cognitive ability using genomic data from 24,092 individuals, finding that 10,000 genes modulate intelligence.

This study examines DNA methylation outlier burden as a marker of biological age and finds it increases with age but is not strongly linked to health outcomes or survival.

This study links birth weight to adult health outcomes and DNA methylation differences, identifying a significant CpG site and associations with biological aging markers.

This study identifies genetic and epigenetic factors associated with inflammatory protein levels in older adults using GWAS and EWAS with a Bayesian framework.

This study examines the genomic architecture of neuroanatomical diversity using SNP data and MRI, finding polygenic influences and environmental factors affecting brain asymmetry.

This study evaluates how different network thresholding methods affect structural brain network properties and their association with age in the UK Biobank.

This study uses Mendelian randomization to show education and intelligence both causally lower Alzheimer's disease risk, with intelligence having an independent effect.

The paper quantifies perivascular spaces (PVS) in brain MRI and links them to retinal microvascular parameters in older adults, finding associations with arteriolar narrowing and reduced branching complexity.

This study identifies DNA methylation loci associated with age-by-sex interactions in a cohort of 2,586 individuals, finding most significant loci are X-linked and linked to disease-related genes.

This study identifies genetic loci associated with household income and links them to biological pathways and cognitive ability, showing genetic differences between income and education.

The paper examines how aging affects brain network integrity and its association with cognitive function using MRI data from two cohorts.

The paper reports epigenome-wide meta-analyses of blood DNA methylation with subcortical brain volumes, identifying significant associations with hippocampal volume and potential biological mechanisms.

This paper introduces DNAm GrimAge, an epigenetic clock that predicts mortality and is associated with multiple brain health measures in older adults.

This study examines how DNAm PhenoAge, a biomarker of biological ageing, relates to health outcomes and cognitive ability across the lifespan, finding that early-life cognitive factors influence later-life health.

The paper analyzes whole genome sequencing data from an isolated Shetland population, finding increased ultra-rare variants in exonic and regulatory regions compared to mainland Scottish populations.

The paper examines genetic and shared couple environmental factors influencing smoking and alcohol use in the UK population using family and couple data.

This study identifies 73 genome-wide significant loci for mood disorders, revealing shared and distinct genetic factors between major depressive disorder and bipolar disorder.

This study identifies genetic correlations between eight pain phenotypes and depression, major depressive disorders, and neuroticism using UK Biobank data and LDSC methods.

The paper examines DNA methylation at the APOE gene in blood samples to assess its association with cholesterol, cognition, and risks of Alzheimer’s and cardiovascular disease.

The paper identifies a genetic general intelligence factor (g) that explains 58.4% of the genetic variance in cognitive traits using genome-wide data from seven cognitive tests.

This study investigates whether genetic variation in the Major Histocompatibility Complex (MHC) is associated with depression risk, finding no significant associations at a conservative threshold.