Nicholas A. Williamson

Global analysis of cancer cell responses to USP9X inhibition

This study identifies WEHI-092, a USP9X inhibitor, and shows it arrests cancer cells in metaphase, suggesting USP9X inhibitors could be selective mitotic poisons.

SMYD5 is a ribosomal methyltransferase which trimethylates RPL40 lysine 22 through recognition of a KXY motif

The paper identifies SMYD5 as a ribosomal methyltransferase that trimethylates RPL40 lysine 22 through a KXY motif, showing its distinct substrate specificity from histone substrates.

Phosphoproteomics implicates glutamatergic and dopaminergic signalling in the antidepressant-like properties of the iron chelator deferiprone

The paper uses phosphoproteomics to identify molecular changes in the prefrontal cortex of 5-HTT KO and WT mice after deferiprone treatment, implicating glutamatergic and dopaminergic signaling in its antidepressant-like effects.

N-Terminomic Changes of Neurons During Excitotoxicity Reveal Proteolytic Events Associated with Synaptic Dysfunctions and Inform Potential Targets for Neuroprotection

The paper identifies proteolytic events in neurons during excitotoxicity using N-terminomics, revealing calpain-mediated cleavage of synaptic proteins and potential therapeutic targets for neuroprotection.

Respiratory strategy at birth initiates distinct lung injury phenotypes in the preterm lamb lung

This study uses mass spectrometry to identify protein-based lung injury phenotypes in preterm lambs based on different ventilation strategies and their associated molecular and physiological outcomes.