Albert J. R. Heck

This study shows that mice with reduced respirasomes maintain normal bioenergetics and physiology, suggesting respirasomes are not essential for basic function but may have other roles.

This paper detects MGUS using LC-MS and determines M-protein sequences from serum, providing molecular detail for monoclonal gammopathies.

The paper quantifies kinase activity dynamics in response to FGF ligands and uses dynamic modeling to reveal pathway regulation and novel kinase involvement.

The paper identifies a previously overlooked complex between AIFM1 and cytochrome c oxidase using mass spectrometry and proteomic approaches, revealing structural insights and potential roles in OXPHOS and cell death.

This study shows mitochondrial CaMKII activation leads to metabolic reprogramming, energetic insufficiency, and dilated cardiomyopathy, with potential therapeutic targets identified.

This study resolves the molecular architecture of human fibrin clots using XL-MS and integrative modeling, revealing structural details of key domains and their role in lateral aggregation and clot formation.

This paper summarizes current XL-MS practices, compares strategies, and proposes common protocols to establish best practice guidelines for accurate and reproducible results.

The paper demonstrates the use of bacterial encapsulins in eukaryotic cells to create nanocompartments for localized enzymatic reactions and multiscale molecular imaging.