Author

Vincent Archambault

Institute for Research in Immunology and CancerORCID 0000-0002-2857-7667Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genetics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:CRISPR screen· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Andrew Chatr‐aryamontriiD· 2 shared Brian T. WilhelmiD· 2 shared Ivan TopisirovićiD· 2 shared Li ZhangiD· 2 shared Mike TyersiD· 2 shared Philippe P. RouxiD· 2 shared Pierre ThibaultiD· 2 shared Sylvie MaderiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersSystems Biology

Andrew Chatr‐aryamontriORCID

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3 papers

Recent·Most cited

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture

Jasmin Coulombe‐Huntington, Thierry Bertomeu, Caroline Huard, Andrew Chatr‐aryamontri, Daniel J. St‐Cyr, María Sánchez‐Osuna, David J. Papadopoli, Karine Normandin, Mohammadjavad Paydar, Shannon McLaughlan, Corinne St‐Denis, Li Zhang, Henry Say, Roger Palou, Chris Stark, , Mike Tyers

The paper presents a chemical-genetic interaction matrix derived from CRISPR/Cas9 screens, revealing drug mechanisms and genetic architecture in human cells.

bioRxiv · Jan 30, 2026 · PreprintSystems Biology

A platform for the systematic interrogation of genetic interactions in human cells: 26 gene by genome-wide double knockout screens as a proof of concept

Andrew Chatr‐aryamontri, Li Zhang, Ndeye Khady Thiombane, Vincent Archambault, Sébastien Carreno, Javier Marcelo Di Noia, Ivan Topisirović, Julie A. Lessard, Philippe P. Roux, Nicolas Pilon, Aaron David Schimmer, Mike Tyers, Corey Nislow, Sylvie Mader, Brian T. Wilhelm, Thierry Bertomeu

The paper introduces a method for systematically studying genetic interactions in human cells using CRISPR/Cas9 screens and demonstrates its effectiveness through 26 gene by genome-wide knockout screens.

bioRxiv · Aug 4, 2025 · PreprintGenetics

Mechanisms of PP2A-Ankle2 dependent nuclear reassembly after mitosis

Jingjing Li, Xinyue Wang, Laia Jordana, Éric Bonneil, Victoria Ginestet, Momina Ahmed, Mohammed Bourouh, Cristina Mirela Pascariu, T.M. Schmeing, Pierre Thibault, Vincent Archambault

This study identifies Ankle2 as a regulatory subunit of PP2A that promotes BAF dephosphorylation and nuclear reassembly by interacting with Vap33 during telophase.

eLife · Feb 18, 2025Peer-reviewedCell Biology