Nicolas Andres Crossley

A founder population reveals genetic variation with major effect on serious mental illness

The paper identifies a founder variant in ADAP1 associated with increased risk of schizophrenia and bipolar disorder in a Colombian genetic isolate.

Analysis of Rare Coding Variation Identifies New Genetic Contributors to Schizophrenia

Ultra-rare damaging coding variants in 87,959 schizophrenia cases and 150,587 controls implicate 40 genes (16 exome-wide, 24 at 5% FDR), half overlapping autism, developmental delay or bipolar genes.

dGAMLSS: An exact, distributed algorithm to fit Generalized Additive Models for Location, Scale, and Shape for privacy-preserving population reference charts

The paper introduces dGAMLSS, a distributed algorithm for fitting GAMLSS models to construct population reference charts without sharing patient data.

Profiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia

This study identifies two ASD subgroups with distinct brain morphology using cross-cultural datasets, highlighting key brain regions associated with subgroup characteristics and autistic traits.

Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study

This study investigates how structural brain alterations in schizophrenia relate to network architecture, finding hub susceptibility and shared epicenters across disease stages and disorders.

Complexity and 1/f slope jointly reflect brain states

This study investigates the relationship between 1/f slope and Lempel-Ziv Complexity in brain states using simulated and empirical data from rat EEG and monkey ECoG.

Reduced resilience of brain state transitions in patients with anti-N-Methyl-D-Aspartate receptor encephalitis

The paper examines brain state transitions in anti-NMDA receptor encephalitis patients, finding reduced network stability and resilience linked to disease severity.

Prodromal manifestations of Parkinson's disease in adults with 22q11.2 microdeletion syndrome

This study identifies prodromal Parkinson's disease features in adults with 22q11.2 microdeletion syndrome, showing signs like hyposmia and dysautonomia, with some evidence of dopaminergic signaling changes.

Brain charts for the human lifespan

The paper introduces brain charts as a standardized resource for benchmarking brain morphology across the human lifespan using MRI data from a large and diverse cohort.

The ascending arousal system promotes optimal performance through meso-scale network integration in a visuospatial attentional task

The paper examines how the ascending arousal system influences large-scale brain network integration during a visuospatial attention task, showing correlations with attentional load and receptor distribution.

Age-dependent genetic variants associated with longitudinal changes in brain structure across the lifespan

This study identifies genetic variants linked to longitudinal brain structure changes across the lifespan using MRI data from 15,640 individuals.