Spencer L. Shorte

Deep learning recognises antibiotic modes of action from brightfield images

This paper uses deep learning to identify antibiotic modes of action from brightfield images without fluorescent labeling, achieving high accuracy in detecting drug exposure and novel mechanisms.

Identification and Functional Characterization of Regulatory Variants in DPP9 Associated with COVID-19 Severity

The paper identifies and functionally characterizes regulatory variants in DPP9 associated with severe COVID-19 by analyzing genetic risk factors and their impact on gene expression and immune cell function.

The Immune Factors Driving DNA Methylation Variation in Human Blood

This study identifies factors influencing DNA methylation variation in human blood, showing that cytomegalovirus infection and aging drive methylation changes, with cellular composition and DNA sequence as key predictors.

Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes

The paper identifies novel genetic and non-genetic factors associated with plasma protein levels in healthy donors, highlighting their impact on immune response variability.

LocalZProjector and DeProj: A toolbox for local 2D projection and accurate morphometrics of large 3D microscopy images.

The paper introduces LocalZProjector and DeProj, tools for accurate 2D projection and morphometric analysis of 3D microscopy images, showing they handle complex data and correct projection distortions.

Reconstruction of cell lineages and behaviors underlying arthropod limb outgrowth with multi-view light-sheet imaging and tracking

The paper uses multi-view light-sheet imaging and a new tracking tool to reconstruct cell lineages and behaviors during crustacean limb development, revealing how cell proliferation and division orientation drive limb outgrowth.