Author

Orsolya Kimbu Wade

Max Planck Institute of BiochemistryORCID 0000-0002-3697-2181Unclaimed ORCID profile · follow to get notified of new preprints

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Cell Biology· 1

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1 Organism:yeast· 1

Frequent Co-Authors

Anja DeiseriD· 1 shared Barbara HummeliD· 1 shared Carina Fernandez GonzaleziD· 1 shared F. Ulrich HartliD· 1 shared Hauke HolthuseniD· 1 shared Isabelle PachmayriD· 1 shared Itika SahaiD· 1 shared Kenneth EhsesiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCell Biology

Anja DeiserORCID

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1 paper

Recent·Most cited

Mitochondrial proteostatic stress disrupts mitoribosome biogenesis and translation

Hauke Holthusen, Victoria A. Trinkaus, Carina Fernandez Gonzalez, Itika Saha, Isabelle Pachmayr, Orsolya Kimbu Wade, Anja Deiser, Barbara Hummel, Patricia Yuste‐Checa, Kenneth Ehses, Roman Körner, Rubén Fernández‐Busnadiego, Ritwick Sawarkar, Ralf Jungmann, Mark S. Hipp, F. Ulrich Hartl

This study shows that proteostatic stress in mitochondria impairs mitoribosome biogenesis and translation, leading to respiratory deficiency and mitochondrial DNA loss.

bioRxiv · Sep 5, 2025 · PreprintCell Biology