Author

Oscar H. Franco

Erasmus MCORCID 0000-0002-4606-4929Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 9 Approach:statistical model· 9 Assay:GWAS summary statistics· 8 Research Focus:GWAS / association mapping· 7 Research Focus:fine-mapping· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

André Gerardus UitterlindeniD· 6 shared Jerome I. RotteriD· 6 shared Thomas MeitingeriD· 5 shared Abbas DehghaniD· 4 shared Annette PetersiD· 4 shared Claudia LangenbergiD· 4 shared Jennifer A. BrodyiD· 4 shared Albert Hofman DiD· 3 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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6 shared papersGenetics

André Gerardus UitterlindenORCID

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9 papers

Recent·Most cited

Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.

Iain Mathieson, Felix R. Day, Nicola Barban, Felix C. Tropf, David M. Brazel, Diana van Heemst, Ahmad Vaez, Natalie R. van Zuydam, Bárbara Domingues Bitarello, Eugene J. Gardner, Evelina Tamerlanov Akimova, Ajuna Azad, Sven Bergmann, Lawrence F. Bielak, Dorret Irene Boomsma, , Vallari Shukla

This study identifies 43 genomic loci associated with reproductive success in 785,604 individuals, showing ongoing natural selection at the FADS locus.

Nature Human Behaviour · Mar 2, 2023Peer-reviewedGenetics

Genetic loci associated with prevalent and incident myocardial infarction and coronary heart disease in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium

Julie M. Hahn, Yi‐Ping Fu, Michael R. Brown, Joshua C. Bis, Paul S. de Vries, Mary Furlan Feitosa, Lisa R. Yanek, Stefan Weiß, Franco Giulianini, Albert V. Smith, Xiuqing Guo, Traci M. Bartz, Diane M. Becker, Lewis C. Becker, Eric Boerwinkle, , Alanna C. Morrison

This study identifies new genetic loci associated with myocardial infarction and coronary heart disease using genome-wide association analyses across multiple cohorts.

PLoS ONE · Nov 13, 2020Peer-reviewedGenetics

Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

S. Fleur W. Meddens, Ronald de Vlaming, Peter Bowers, Casper A.P. Burik, Richard Karlsson Linnér, Chan Wook Lee, Aysu Okbay, Patrick Turley, Cornelius A. Rietveld, Mark Alan Fontana, Mohsen Ghanbari, Fumiaki Imamura, George McMahon, Peter J. van der Most, Trudy Voortman, , Philipp Koellinger

This study identifies genetic loci associated with macronutrient intake and links them to health outcomes using GWAS in over 235,000 individuals.

Molecular Psychiatry · May 11, 2020Peer-reviewedGenetics

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

Amand Floriaan Schmidt, Michael Vaclav Holmes, David Preiss, Daniel I. Swerdlow, Spiros Denaxas, Ghazaleh Fatemifar, Rupert Faraway, Chris Finan, R Thomas Lumbers, Albert Henry, Dennis Valentine, Zammy Fairhurst-Hunter, Fernando Pires Hartwig, Bernardo Lessa Horta, Elina Hyppönen, , Albert Hofman D

The paper analyzes genetic variants at the PCSK9 locus to assess their phenotypic effects on lipid levels and disease outcomes, finding concordance with PCSK9 inhibitor trials for myocardial infarction but discordance for type 2 diabetes.

BMC Cardiovascular Disorders · Oct 29, 2019Peer-reviewedGenetics

Novel DNA methylation sites of glucose and insulin homeostasis: an integrative cross-omics analysis

Jun Liu, Elena Carnero‐Montoro, Jenny van Dongen, Samantha Lent, Ivana Nedeljkovic, Symen Ligthart, Pei-Chien Tsai, Tiphaine C. Martin, Pooja R. Mandaviya, Rick Jansen, Marjolein J. Peters, Liesbeth Duijts, Vincent W. V. Jaddoe, Henning W. Tiemeier, Janine F. Felix, , Cornelia M. van Duijn

This study identifies nine novel DNA methylation sites associated with fasting glucose and insulin levels by integrating cross-omics data from multiple cohorts.

Nature Communications · Jun 13, 2019Peer-reviewedGenomics

Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

Cavin K Ward-Caviness, Paul S. de Vries, Kerri L. Wiggins, Jennifer E. Huffman, Lisa R. Yanek, Lawrence F. Bielak, Franco Giulianini, Xiuqing Guo, Marcus Edi Kleber, Tim Kacprowski, Astrid Petersman, George Davey Smith, Fernando Pires Hartwig, Jack Bowden, Gibran Hemani, , Alanna C. Morrison

This paper evaluates the causal effect of fibrinogen on coronary heart disease using Mendelian randomization, finding a small effect with multi-variant methods but not with single variant approaches.

PLoS ONE · May 10, 2019Peer-reviewedGenetics

A Comprehensive Evaluation of the Genetic Architecture of Sudden Cardiac Arrest

Foram N. Ashar, Rebecca N. Mitchell, Christine M. Albert, Christopher Newton‐Cheh, Jennifer A. Brody, Martina Müller‐Nurasyid, Anna Moes, Thomas Meitinger, Angel C. Y. Mak, Heikki V. Huikuri, Juhani M. Junttila, Philippe Goyette, Sara L. Pulit, Raha Pazoki, Michael W.T. Tanck, , Nona Sotoodehnia

This study evaluates the genetic architecture of sudden cardiac arrest through GWAS and Mendelian randomization, finding genetic correlations with CAD, height, BMI, and electrical instability traits.

European Heart Journal · Jul 20, 2018Peer-reviewedGenetics

Genome-wide association meta-analysis of PR interval identifies 47 novel loci associated with atrial and atrioventricular electrical activity

Jessica van Setten, Jennifer A. Brody, Yalda Jamshidi, Brenton R. Swenson, Anne M. Butler, Harry Campbell, M. Fabiola Del Greco, Daniel S. Evans, Quince Gibson, Daniel Fannar Gudbjartsson, Kathleen F. Kerr, Bouwe P. Krijthe, Leo‐Pekka Lyytikäinen, Christian Müller, Martina Müller‐Nurasyid, , Paolo Gasparini

This study identifies 47 novel genetic loci associated with PR interval through genome-wide association meta-analysis across multiple populations.

bioRxiv · Jan 17, 2018 · PreprintGenetics

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Anubha Mahajan, Daniel Taliun, Matthias Thurner, Neil R. Robertson, Jason Torres, Nigel William Rayner, Valgerður Steinthórsdóttir, Robert A. Scott, Niels Grarup, James P. Cook, Ellen M. Schmidt, Matthias Wuttke, Chloé Sarnowski, Reedik Mägi, Jana Nano, , Claudia Langenberg

This study fine-maps type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps, identifying 73 variants with >80% posterior probability of association.

bioRxiv · Jan 9, 2018 · PreprintGenomics