Konrad Rawlik

Genetic score omics regression and multi-trait meta-analysis detect widespread cis-regulatory effects shaping bovine complex traits

GSOR and MTAO detect widespread cis-regulatory effects on bovine complex traits by linking gene expression with genetic scores and multi-trait associations.

Data Resource Profile: Whole Blood DNA Methylation Resource in Generation Scotland (MeGS)

The paper describes a large DNA methylation dataset from the Generation Scotland cohort, providing methylation profiles and associated phenotypes for research purposes.

Proteome-wide Mendelian randomization study implicates inflammaging biomarkers in retinal vasculature, cardiometabolic diseases and longevity

A compendium of genetic regulatory effects across pig tissues

The paper presents PigGTEx, a resource linking genetic variants to transcriptomic phenotypes in pigs, showing pigs' similarity to humans in gene regulation and complex traits.

Frequency and phenotype associations of rare variants in five monogenic cerebral small vessel disease genes in 200,000 UK Biobank participants with whole exome sequencing data

The paper examines rare variants in monogenic cerebral small vessel disease genes in UK Biobank participants, finding limited phenotype associations and suggesting issues with previous gene-phenotype links.

A comprehensive catalogue of regulatory variants in the cattle transcriptome

The paper constructs a cattle Genotype-Tissue Expression atlas and identifies genetic regulatory variants linked to gene expression and traits in cattle.

Expanded Analysis of Pigmentation Genetics in UK Biobank

The paper analyzes pigmentation phenotypes in UK Biobank using DISSECT to identify new candidate genes and explore sex differences and geographic patterns in hair and skin color.

Sexual differences in genetic architecture in UK Biobank

This study examines sexual differences in genetic architecture across 530 traits in 450,000 UK Biobank individuals, finding sex-specific heritability and genetic correlations.

SNP heritability: What are we estimating?

The paper analyzes SNP heritability estimation methods and shows that the correct model for inference does not require knowledge of the true genetic architecture.

Identification of epigenome-wide DNA methylation differences between carriers of APOE ϵ4 and APOE ϵ2

This study identifies epigenome-wide DNA methylation differences between APOE ε4 and ε2 carriers in whole blood, implicating lipid-related genes.

Proteome-by-phenome Mendelian Randomisation detects 38 proteins with causal roles in human diseases and traits

Birth weight predicts psychiatric and physical health, cognitive function, and DNA methylation differences in an adult population

This study links birth weight to adult health outcomes and DNA methylation differences, identifying a significant CpG site and associations with biological aging markers.

Epigenome-wide analyses identify DNA methylation signatures of dementia risk

The paper identifies DNA methylation signatures associated with dementia risk factors in blood samples from individuals without Alzheimer's disease.

Identification of novel differentially methylated sites with potential as clinical predictors of impaired respiratory function and COPD

This study identifies 29 differentially methylated sites associated with respiratory function and COPD, showing improved prediction of COPD risk when added to clinical models.

Indirect assortative mating for human disease and longevity

The paper shows that parental longevity and disease history are correlated in UK Biobank couples, suggesting indirect assortative mating based on factors like BMI and genetics.

The genetic architecture of hair colour in the UK population

The paper maps the genetic architecture of hair colour in the UK population, identifying multiple loci and epistatic interactions contributing to red and blonde hair.

An atlas of genetic associations in UK Biobank

The paper presents an atlas of genetic associations for 617 traits using UK Biobank data, enabling easy access to GWAS results without high computational costs.

Accurate genetic profiling of anthropometric traits using a big data approach

The paper develops a genetic prediction model for anthropometric traits using a large dataset, achieving higher accuracy than previous methods.