Harald Stachelscheid

A human iPS cell line for ready-to-use human iAstrocytes that support human neurons

This paper introduces a human iPSC line that generates iAstrocytes capable of supporting human neuron networks in co-cultures.

StemCNV-check: a pipeline for human pluripotent stem cell (hPSC) genomic integrity control using SNP array data and copy number variant scoring

The paper introduces StemCNV-check, a pipeline for assessing genomic integrity in human pluripotent stem cells using SNP array data and CNV scoring.

An autologous human iPSC-derived 3D organoid infection model for preclinical testing of antiviral T cells

The paper develops a 3D lung organoid model to assess antiviral T cell efficacy in vitro, demonstrating T cell-mediated cytotoxicity against influenza virus.

SteMClass: A Novel DNA Methylation-Based Classifier for iPSC In Vitro Differentiation States.

SteMClass is a DNA methylation-based classifier that accurately identifies iPSC differentiation states across protocols and datasets.

DTX4 regulates neural progenitor transitions during cortical development

This study identifies DTX4 as a regulator of neural progenitor transitions during cortical development, showing its role in maintaining radial glia identity and preventing intermediate progenitor generation.

Combined stem cell and predictive models reveal flavin cofactors as targets in metabolic liver dysfunction

The paper combines stem cell models and computational predictions to identify flavin cofactors as therapeutic targets for metabolic liver dysfunction.

Spatiotemporal expression of thyroid hormone transporter MCT8 and THRA mRNA in human cerebral organoids recapitulating first trimester cortex development

The paper characterizes the spatiotemporal expression of MCT8 and THRA in human cerebral organoids, showing their expression patterns align with early cortical development and response to thyroid hormone treatment.

FRC-QE: A robust and comparable 3D microscopy image quality metric for cleared organoids

This paper introduces FRC-QE, a 3D image quality metric for cleared organoids, showing it robustly captures clearing efficiency differences across protocols and microscopy modalities.

Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors

This study shows HERV-K(HML-2) RNA activates TLR8 and Tlr7, causing neurodegeneration in mice and correlating with AD in humans.