Thomas Kurz

3-Hydroxypropanamidines: from antiplasmodial leads to a novel antibacterial scaffold

This study evaluates the antibacterial activity and properties of three 3-hydroxypropanamidines against Gram-positive and Gram-negative bacteria.

Small-molecule inhibitor of C-terminal HSP90 dimerization modulates autophagy and functions synergistically with mTOR inhibition to kill cisplatin-resistant cancer cells

This paper introduces a C-terminal HSP90 dimerization inhibitor, VWK147, which induces cell death in cisplatin-resistant cancer cells and synergizes with mTOR inhibition to enhance therapeutic efficacy.

α-Aminooxyacetic acid derivatives acting as pro-drugs against Mycobacterium tuberculosis

This study identifies novel anti-TB pro-drugs based on α-aminooxyacetic acid that are effective against M. tuberculosis and show low cytotoxicity.

Development of a Bipyrimidineamide based α-Helix Mimetic Lead Compound for efficient Targeting of MDM2 in Triple-Negative Breast Cancer

This study develops a bipyrimidineamide-based α-helix mimetic compound, VWK603, which effectively targets MDM2 in TNBC cells with lower toxicity than Nutlin-3a.