mouse

This study identifies Tfcp2l1 and Thrap3 as regulators of ESC self-renewal through exon-5 splicing of Jmjd1c and DNA repair pathway choice.

PRISM simultaneously decontaminates ambient RNA and corrects doublets in spatial transcriptomics data, achieving high accuracy and purity in a mouse cerebellum dataset.

This study maps quantitative trait loci modifying glycemia in MafAS64F-driven dysglycemia using genetically diverse mice.

This paper introduces [18F]GPR39 2.1, a PET radiotracer for noninvasive imaging of GPR39, showing high specificity and sensitivity in vivo.

The paper shows that impaired gut microbiota fermentation of inulin leads to intestinal inflammation in mice, highlighting the importance of microbial metabolism in fiber tolerance.

This study shows MmuPV1 and HPV16 E6 oncoproteins disrupt NF-κB signaling by increasing nuclear IKKα localization, suggesting a shared mechanism in papillomavirus persistence.

This study generates transgene-free iPSCs from the fat-tailed dunnart, demonstrating their pluripotency and potential for use in conservation biotechnology.

This study identifies Lck and Fyn as essential Src family kinases required for T cell transendothelial migration through their regulation of PI3K signaling and cytoskeletal dynamics.

This study shows ATF3 helps macrophages manage cholesterol during metabolic stress by balancing inflammation and sterol-responsive gene expression.

This study links cochlear immunity to adjacent bone marrow through anatomical and day-night profiling in mice, revealing synchronized clocks and immune cell dynamics.

This study shows that combining serotonin reuptake inhibition with NMDAR antagonism reduces reward-related effects while maintaining rapid antidepressant efficacy.

The paper compares gene regulatory networks in mouse and pig limb development to reveal conserved and divergent regulatory programs and mechanisms of developmental robustness.

The paper investigates experience-dependent plasticity in somatostatin interneurons and identifies two-pore potassium (K2P) channels as a mechanism underlying this plasticity.

This study shows that Saccharomyces cerevisiae persistence in mice is polygenic with strong additive effects and minimal host-genotype interactions.

The paper maps synaptic projections in the mouse midbrain periaqueductal gray (PAG) to reveal modular output populations that extend the classical columnar framework for understanding behavior control.

The paper develops SA-eGRASP to map and track potentiated synapses in the mouse hippocampus following learning and uses it to study long-term synaptic dynamics.

This study shows that dietary changes in n-3 LC-PUFA supply alter brain phospholipid composition but not ganglioside composition in mice.

This paper demonstrates a drug-free method using laser-induced vapor nanobubbles to create immunogenic whole-cell vaccines for bladder cancer, showing reduced tumor growth and immune activation.

The paper examines genetic and phenotypic variation in deer mice across elevation gradients, finding predictable patterns in extreme environments that could inform species vulnerability to environmental change.

This study shows that tissue-like viscoelastic substrates enhance muscle stem cell expansion by creating mechanical memory through focal adhesion stabilization and Rac-Akt signaling.

This study shows that mechanical stress influences age-related changes in vestibular hair cell differentiation and regeneration through Notch signaling.

The paper identifies a PTN-rich MSC subtype that enhances cartilage repair in KOA by modulating key inflammatory and repair pathways.

This study identifies SAMP1 as a protector of alveolar type 2 cells against DNA damage-induced senescence and shows its role in limiting pulmonary fibrosis in a mouse model.

This study demonstrates the transferability of homoserine lactone sensors between Bacillales bacteria, enabling programmable interphyla communication between Gram-negative and Gram-positive species.

This paper uniformly re-analyzes public omics data from exercise studies in humans and rodents, providing standardized effect sizes and meta-analyses across multiple tissues and molecular layers.

The paper shows that mechanical sorting, driven by adhesion and contractility differences, maintains basal-luminal compartmentalization and influences lineage outcomes in glandular epithelia.

This study shows that IL4Ra signaling in SP thymocytes prolongs their medullary dwell time, enhancing their maturation and functional capabilities.

This study uses CRISPR-mediated lineage tracing to show that adipose depot identity is shaped by anatomical niche rather than embryonic lineage.

This paper uses multimodal imaging to link molecular identity with nanoscale 3D cell morphology in opossum cortical cultures, showing how molecular changes correlate with morphological differences during development.

This study identifies the circadian clock's role in coordinating the Notch-to-Wnt signaling switch to enhance regenerative myogenesis in muscle stem cells.