host-pathogen & immune response

The paper investigates how viral anti-defense systems vary with genomic traits, host immunity, and environmental stress across microbial ecosystems.

The paper introduces a high-throughput SPR array to profile GAG-protein interactions, validating it with known proteins and identifying new interactions.

This study shows that HbAS and HbAC red blood cells increase Plasmodium falciparum sexual conversion rates compared to HbAA, suggesting a host genetic factor affecting malaria transmission.

This study develops a reverse genetics system for Yezo virus to investigate the role of its glycoprotein N-terminal region in replication across mammalian and tick hosts.

This study shows obesity impairs B7-H3.CAR-T cell antitumor activity and memory formation in TNBC by altering cytokine profiles and metabolic function.

This study identifies expanded protocadherin-1 usage by hantaviruses and shows differential neutralization by antibodies.

This paper develops a long-term human skin platform to model chronic inflammation, aging, and environmental stress, showing its utility in testing therapeutic interventions.

The paper analyzes the extreme 2025 wildfire season in Southwestern Europe, identifying increased fire intensity, nocturnal spread, and significant ecological and health impacts.

This study evaluates the reliability of using wing biopsies to detect blood-borne pathogens in bats, finding lower detection rates compared to blood but still viable for initial pathogen discovery.

The paper examines life history traits across four clades of the chiral livebearer fish Xenophallus umbratilis to assess conservation needs and adaptive evolution.

This study investigates how temperature and salinity affect msh promoter activity and MSHA pilus production in Vibrio cholerae, revealing their impact on biofilm formation and environmental persistence.

This study shows that Psi RNA binding promotes a conformational change in HIV-1 Gag from compact to extended, essential for viral particle assembly, supported by FRET and molecular dynamics simulations.

This paper develops covalent EGFR inhibitors targeting cysteine 775 and 797, showing improved efficacy and resistance delay in osimertinib-resistant models.

This study shows that Bacteroides thetaiotaomicron-derived extracellular vesicles inhibit melanoma growth via immune activation rather than direct cytotoxicity.

This study compares acute infection and viral rebound dynamics in ART-treated infant rhesus macaques using a mathematical model to identify increased infected cell death during rebound.

The paper investigates the evolutionary conservation of DELLA protein functions in liverworts and finds GA-independent developmental roles are conserved, but DELLA is not involved in mycorrhizal symbiosis.

This study identifies a bacterial protease that influences phage susceptibility and links it to host epithelial responses in ulcerative colitis.

This study identifies EIDD-3525 as a broad-spectrum antiviral against alphaviruses that inhibits RNA replication by targeting the nsP4 polymerase.

The paper identifies autolytic ability as a key factor in beta-lactam potentiation against MRSA by blocking cell wall precursor production through a mechanism distinct from the Lipid II pathway.

This study uses continuous cultivation to investigate episymbiont-host interactions, revealing distinct infection patterns and the role of host-binding factors in shaping these dynamics.

This study identifies MX1 and IFITM1 as IFN-gamma-induced factors that inhibit VZV replication and shows JAK-STAT suppression promotes viral replication in keratinocytes.

The paper shows a dengue virus mutant lacking N153 glycosylation is more susceptible to neutralizing antibodies, as evidenced by increased Fab occupancy and slower dissociation rates.

This study characterizes the kinetics of Bcbva infection and toxin production in a murine cutaneous model, revealing rapid spore germination, toxin diffusion, and systemic dissemination leading to septicemia.

This study shows that loss of EF-P increases survival of Bacillus subtilis to fluoroquinolones, highlighting EF-P's role in susceptibility through post-translational modification and interaction with DNA repair pathways.

The paper shows that expressing a constitutively active CycT1 protein in resting CD4+ T cells delays viral latency.

This paper shows that masking phosphatidylserine with MFG-E8 prevents neuronal loss in two Drosophila neurodegeneration models, improving motor function and lifespan.

This study uses a genome-wide CRISPR-Cas9 screen to identify host factors essential for EBV B cell infection, revealing new pathways and potential therapeutic targets.

This study identifies a novel E3 ligase secreted by Pseudomonas aeruginosa that regulates virulence through ubiquitin modification.

This study shows that better adherence to the DASH diet in midlife and early elderhood improves late-life verbal memory and brain health through structural and neurovascular mechanisms.