Neurotransmitter Receptor Influence on Behavior

The paper proposes a temporal difference model that explains how dopamine neurons encode different reward dimensions and adapts behavior based on physiological needs.

This study identifies pleiotropic effects of dopaminergic and serotonergic genes on addiction, aggression, and related behaviors through GWAS and TWAS analyses across multiple datasets.

This study shows that phasic dopamine signaling in VTA neurons regulates force exertion during learning, not reward prediction error.

This study examines how D1- and D2-neurons in the nucleus accumbens encode positive and aversive associations during Pavlovian conditioning, showing dynamic changes in their activity.

This study shows that adolescent morphine exposure impairs cognitive flexibility in female mice but not males, with effects persisting into adulthood for flexibility but not discriminative learning.

The paper shows that cocaine seeking and taking are oppositely regulated by dopamine in rats, with cue-evoked dopamine changes linked to relapse and escalated consumption.

The paper shows that prelimbic cortical neurons encode hedonic value during solution consumption, with distinct activity patterns for water, ethanol, and sucrose, and these patterns are altered by ethanol dependence.

This study shows that serotonin release from dorsal raphe-to-mPFC neurons modulates cognitive flexibility in mice by enhancing extradimensional rule shift performance.

This study shows that negative reinforcers reduce cocaine self-administration in rats, with no significant increase in cocaine choice even after extended access.

This study investigates the role of NAcD1-MSN-SNr pathway in reward learning and motor behaviors through optogenetic activation.

This study shows that a ketogenic diet prevents anxiety-like behavior in male mice during sucrose withdrawal but not in females.

This study shows that serotonin release from the dorsal raphe nuclei to the orbitofrontal cortex enhances reversal learning by increasing neuronal excitability and synaptic plasticity.

The paper investigates how dopamine systems in the basal ganglia process reward prediction based on working memory versus random rewards in rats and mice.

This paper identifies a novel hypothalamic-midbrain circuit that supports model-based learning and shows its alteration in methamphetamine use.

This study shows that 5-HT1A and 5-HT1B receptor blockade separately affects motivation by altering sensitivity to cost and reward in monkeys.

This study shows that repeated footshock stress increases cocaine self-administration in both male and female rats, with CB1R signaling playing a role in this effect across sexes.

This study shows that striatal enkephalin is not required for cocaine reward acquisition but is necessary for maintaining the learned association during extinction.

This study shows that serotonin in the dorsal raphe nucleus and insular 5-HT2C receptors modulate social responses to stressed rats, with effects observed in both males and females.

The paper shows that dopaminergic signals for reward and performance shift during courtship in songbirds, with signals routed through distinct pathways based on social context.

This study examines sex-specific changes in motivated behavior and mesoaccumbal dopamine subcircuit plasticity during protracted morphine withdrawal in mice, finding male-specific reductions in non-drug reward motivation linked to lateral DA subcircuit alterations.

This study shows that paternal morphine exposure increases morphine self-administration in male offspring but not females, with region-specific neural changes in reward-related brain areas.

The paper identifies distinct roles of claustrum subregions in anxiety and cocaine addiction susceptibility following adolescent cocaine exposure.

This study uses PET and fMRI to show endogenous opioid release in the hippocampus and increased hemodynamic activity in brain regions associated with sexual arousal following orgasm.

Mouse locus coeruleus norepinephrine neurons split into wide-spike and thin-spike subtypes that oppositely encode positive reward prediction errors and reward omission to drive reinforcement learning.

The paper decomposes mouse behavior in the sucrose preference test to identify latent behavioral subcomponents and their relationship with stress and optogenetic interventions.

This paper proposes a model where vector-valued dopamine signals enhance learning of continuous outputs in the striatum using a recurrent network and a local plasticity rule.

This study investigates the role of D1R- and D2R-SPNs in the nucleus accumbens in modulating social behavior and related neuropsychiatric traits in mice.

This study identifies Nav1 as a gene regulating learning, memory, and responses to addictive drugs through synaptic balance changes in the cortex and hippocampus.

This study investigates the role of alpha- and beta-adrenergic receptors in compulsion-like alcohol drinking using rat models and finds that propranolol reduces alcohol intake through mechanisms not limited to specific brain regions.