Neurotransmitter Receptor Influence on Behavior

Paraventricular Thalamus Neurons Encode Early-life Adversity and execute Consequent Sex-dependent Disruptions of Adult Reward Behaviors

The paper identifies sex-dependent roles of paraventricular thalamus neurons in mediating the effects of early-life adversity on adult reward behaviors in mice.

Individual Differences in Dopaminergic Modulation of Exploration-Exploitation Behaviour

This study investigates how dopamine levels affect exploration-exploitation behavior in humans, finding that cognitive capacity and sex moderate L-DOPA effects on decision-making.

The Role of Anterior Insular Parvalbumin GABAergic Interneurons in Impulsivity-Related and Alcohol-Seeking Behaviors

This study shows that insular parvalbumin interneurons modulate impulsivity and alcohol consumption, with reduced activation linked to increased impulsivity and alcohol intake in adolescents.

Using Light to Establish Habits in Laboratory Mice

This study validates an operant paradigm where mice lever-press for light as a reward, showing light can drive behavior independently of physiological needs or hedonic responses.

Differential contributions of striatal dopaminergic pathways to visuomotor conditional learning

The paper investigates how different striatal dopaminergic pathways contribute to visuomotor conditional learning, finding that only nigrostriatal DA is necessary for learning.

Glucose and fructose differently mediate alcohol cocktail drinking in female and male rats: interaction of glucose and alcohol on post-ingestive behavior

This study shows that glucose and fructose differently affect alcohol drinking in male and female rats, with glucose enhancing alcohol intake and influencing post-ingestive behavior.

Systemic administration of the mGluR2/3 antagonist LY341495 disrupts reward-related behaviors across ingestive and social domains in mice

This study shows that LY341495, an mGluR2/3 antagonist, reduces reward-related behaviors in mice across ingestive and social domains without affecting general motor function.

Selective dysregulation of serotonin dynamics in the anterior cingulate cortex and central amygdala following binge alcohol consumption

This study identifies region-specific serotonin signaling changes in the ACC and CeA after binge alcohol consumption, showing differential effects on reward and aversion behaviors.

Reproducible Human Reward Imaging Phenotypes Exhibit Differential Sensitivity to Dopamine D2 Receptor Antagonism

The paper identifies two reproducible reward imaging phenotypes linked to dopamine D2 receptor function and shows differential responses to antipsychotic drugs.

Cholinergic-dependent dopamine signals in mouse dorsomedial striatum are regulated by frontal but not sensory cortices

The paper shows that visual stimuli evoke dopamine in the dorsomedial striatum via cholinergic-dependent mechanisms, driven by frontal cortices rather than sensory cortices.

NMDA receptor ablation in medial prefrontal cortex disrupts value updating and reward history integration

This study shows that NMDA receptor loss in the medial prefrontal cortex impairs value updating and reward history integration in mice, mimicking schizophrenia-like cognitive deficits.

Genetic Modulation of Oxycodone Self-Administration Trajectories: From Initiation to Escalating Burst Patterns

This study identifies strain-dependent genetic influences on oxycodone self-administration patterns in rats, revealing differences in acquisition, escalation, and burst-like responding.

Social isolation recruits amygdala-medial prefrontal cortex projections to escalate alcohol drinking in male mice

This study identifies a BLA-mPFC neural pathway through which social isolation increases alcohol drinking in male mice by altering prefrontal cortex activity.

Calbindin Stratifies Midbrain Dopaminergic Neurons Governing Distinct Aspects of Locomotion

This study identifies distinct roles of calbindin-expressing and non-expressing midbrain dopaminergic neurons in locomotion and motor learning through genetic ablation and chemogenetic approaches.

Hypothalamic Representation of Aggressiveness across Mouse Strains

The paper investigates genetic and neuronal factors influencing aggression in mice, finding strong genetic control and a role for VMHvl neurons.

Mesolimbic and mesocortical pathways differentially support fentanyl-context associations

This study investigates how VTA-NAc and VTA-PFC circuits contribute to fentanyl-context associations and identifies distinct dopamine receptor roles in context-seeking behavior.

Sensory stimulation triggers different spike responses in serotonin and dopamine neurons in the dorsal midbrain tegmentum.

The paper shows that serotonin and dopamine neurons in the dorsal midbrain tegmentum respond differently to sensory stimuli, with distinct activation patterns following aversive inputs.

Thalamo-accumbal circuit adaptations following extended oxycodone abstinence.

This study examines sex differences in relapse vulnerability after oxycodone abstinence by analyzing neural circuit adaptations in the thalamo-accumbal pathway in male and female rats.

Cued unpredictable intermittent access exacerbates loss of control over ethanol drinking

This study shows that unpredictable intermittent access to ethanol increases dependence and aversion-resistant drinking in rats compared to continuous access.

Chemogenetic Inhibition of Lateral Hypothalamus Inputs to the Paraventricular Thalamus Reduces Goal-Tracking in a Behaviorally Flexible Subgroup of Male Rats

The paper inhibits the LH-PVT pathway in rats and finds it reduces goal-tracking behavior, particularly in intermediate responders.

Acute stress induces circuit-specific alterations in mesolimbic and nigrostriatal inhibitory transmission and potentiates operant learning

This study shows acute stress enhances operant learning in rats by altering inhibitory transmission in mesolimbic and nigrostriatal circuits, specifically affecting GABAergic inputs to dopamine neurons.

Acute opioid responses are modulated by dynamic interactions of Oprm1 and Fgf12

This study identifies time-dependent epistatic interactions between Oprm1 and Fgf12 that modulate opioid-induced locomotion in mice and links Fgf12 to opioid behavior in humans.

Stimulus-Dependent Dopamine Dynamics from LocusCoeruleus Axons

This study identifies the physiological and behavioral conditions that trigger dopamine release from locus coeruleus axons, showing modality-dependent release constraints.

Stress-induced adaptations in nucleus accumbens dopamine D1 receptor-expressing cells correspond to social avoidance behavior in male mice

The paper links stress-induced increases in D1R-associated dynorphin signaling in the nucleus accumbens to social avoidance behavior in male mice.

Intermittent Cocaine Use Patterns, Not Total Intake, Predict Cue-induced Drug Seeking in Rats

This study shows that individual cocaine use patterns, not total intake, predict cue-induced relapse in rats under intermittent access conditions.

5-HT4 receptor ligand RS67333 modulates striatal acetylcholine and dopamine release via inhibition of acetylcholinesterase

This study shows RS67333 modulates striatal dopamine and acetylcholine release by inhibiting acetylcholinesterase, not through 5-HT4R activation, and highlights the potential of AChE inhibitors for treating ACh/DA disorders.

Learning dynamically regulates stimulus discrimination of ventral striatal D1 receptor expressing neurons

This study shows that D1 medium spiny neurons in the ventral striatum show increased selectivity for reward-paired cues during learning, while D2 neurons show less change, indicating a dynamic role for D1 neurons in stimulus discrimination.

Semaglutide Alters Behaviour and Nucleus Accumbens Oscillatory Activity in Healthy Mice

This study shows that semaglutide affects behavior and neural oscillations in healthy mice, suggesting potential therapeutic implications beyond metabolic disorders.

Transcriptional response to chronic long-access fentanyl self-administration in rat habenula and amygdala

This study identifies transcriptomic changes in rat habenula and amygdala after chronic fentanyl self-administration, linking them to human cell types and risk genes for addiction.

Chronic ethanol self-administration alters dopamine in the caudate nucleus and putamen of rhesus macaques in a sex-dependent manner

This study shows chronic ethanol self-administration in rhesus macaques alters dopamine signaling in the caudate and putamen, with sex-specific differences in release and uptake.