Antibiotic Resistance in Bacteria

The paper characterizes recalcitrant enterococcal bacteremia through clinical and genomic analysis, finding species-specific genetic adaptations in persistent infections.

The paper introduces Context-Seq, a CRISPR-Cas9 targeted nanopore sequencing method to study AMR transmission between humans and animals, identifying shared ARG clusters and potential pathogenic hosts.

This paper uses machine learning to predict antimicrobial resistance (AMR) across ESKAPE pathogens by analyzing genomic data and identifying molecular features associated with drug resistance.

This study identifies DcaP-family porins as essential for carboxylic acid utilization and infection in A. baumannii, showing functional redundancy and validating their potential as therapeutic targets.

The study analyzes the gut resistome of the Wayampi, revealing similar antibiotic resistance gene richness to Europeans but higher metal resistance gene diversity, highlighting shared and distinct resistance patterns.

This study shows that the ponAL421P mutation in PBP1 increases penicillin MIC above the clinical breakpoint and persists in N. gonorrhoeae despite penicillin's removal from treatment guidelines.

The paper investigates collateral sensitivity and cross-resistance networks in six bacterial species after induced resistance to six antibiotics, finding specific patterns and genetic mechanisms.

This study shows avibactam resistance emerges rapidly through a large mutational target, with no significant growth rate difference between resistant and susceptible strains.

This study analyzes A. baumannii isolates from the Orang Asli community in Malaysia, revealing genetic diversity, virulence factors, and antibiotic resistance genes similar to clinical isolates.

This study identifies mutations in the ampD gene of Chromobacterium violaceum that lead to overproduction of beta-lactamases and increased resistance to beta-lactam antibiotics.

This paper engineers a prodrug that selectively suppresses β-lactam-resistant bacteria in mixed cultures by exploiting ESBL activity.

The paper investigates eco-evolutionary feedbacks between restriction-modification systems and antimicrobial resistance gene acquisition using modeling and genome analysis.

This study analyzes mobile genetic elements in Acinetobacter isolates to understand how they facilitate antimicrobial resistance gene dissemination across different environments.

The paper introduces a knowledge graph-based framework to detect horizontal gene transfer events contributing to antimicrobial resistance, achieving high accuracy in predictions and identifying key dissemination hubs.

The paper evaluates the presence of Acinetobacter-associated class D carbapenemase genes in Enterobacterales isolates in the U.S. and finds only one case of blaOXA-23-like gene in Klebsiella pneumoniae.

This study investigates resistance mechanisms to ceftazidime-avibactam and meropenem in Pseudomonas aeruginosa using multi-omics profiling and identifies strain-specific and common genetic factors associated with resistance.

This study systematically analyzes antibiotic resistance gene transfers between evolutionary distant bacteria, identifying 661 inter-phyla transfers and highlighting differences in transfer frequency and mechanisms across ARG classes and phyla.

The paper investigates how tazobactam affects multidrug resistance in E. coli and Klebsiella pneumoniae using transposon mutagenesis, finding it selects for efflux pumps and membrane permeability changes.

This study compares heavy metal resistance and antibiotic resistance in ESBL-producing and non-ESBL-producing E. coli using MIC testing, PCR, and whole genome sequencing.

This study identifies cefiderocol resistance genes in environmental samples using functional metagenomics, revealing beta-lactamases and mobile genetic elements.

This study identifies multidrug-resistant Escherichia coli in household water and demonstrates the transmissibility of antibiotic resistance genes through conjugation.

The paper characterizes blaNDM-carrying plasmids in K. pneumoniae isolates from Pakistan, identifying genetic diversity and resistance genes.

This study identifies two survival strategies in conjugative plasmids that correlate with their host range and antibiotic resistance gene dissemination.

ARGContextProfiler improves accuracy in identifying antibiotic resistance gene contexts in metagenomic data using assembly graphs and read mapping.

The paper identifies two types of antimicrobial resistant bacteria in the gut microbiome after antibiotic treatment and shows how one type persists and reshapes the microbial community.

This study investigates the origin and evolution of the gonococcal beta-lactamase plasmid pbla, showing its acquisition from Haemophilus ducreyi and its role in antibiotic resistance, with implications for public health.

This study uses computational methods to analyze dynamic differences among Pen β-lactamases from Burkholderia spp., identifying critical mutations and functional hotspots.

This study sequenced A. baumannii ST19 genomes and found a loss of the T6SS locus, replaced by antibiotic resistance transposons, potentially enhancing horizontal gene transfer and population-level competitiveness.

This study analyzes KpSC populations across human, animal, and marine sources in Norway, showing distinct yet overlapping populations with limited recent transmission between niches.

This study investigates how oxygen levels affect antimicrobial resistance gene performance in Enterobacterales, showing significant variations in resistance under aerobic and anaerobic conditions.