Antifungal resistance and susceptibility

This study identifies a mutation rate increase in a multi-azole resistant Aspergillus fumigatus clade, linking it to rapid antifungal resistance evolution.

This study shows that C. albicans develops resistance to NFAP2 with fewer genetic changes and less phenotypic impact than to fluconazole, suggesting NFAP2 is a promising antifungal with low resistance potential.

This study investigates how azole and phenothiazine drugs activate the C. glabrata Pdr1 pathway, showing distinct kinetics and mechanisms of CDR1 induction.

This study uses single-cell transcriptomics to identify immune responses and IL-1Ra-IL-1R evasion strategies in C. auris skin infection.

This study evaluates the antifungal potency of terbinafine against Exophiala dermatitidis using in vitro methods and identifies its effectiveness in biofilm inhibition and combination therapy.

This paper shows EGFR signaling is essential for host defense against invasive aspergillosis, as its inhibition worsens infection outcomes in immunosuppressed mice.

The paper identifies Als5 and Scf1 as complementary adhesins in Candida auris that promote cell-cell interaction and biofilm formation through functional redundancy.

This study identifies Hog1 MAP kinase as essential for Candida auris skin colonization and intradermal persistence through RNA-seq and phenotypic analyses.

This paper identifies the riboflavin biosynthetic pathway as a novel antifungal target in Candida species, showing that key enzymes are essential and that riboflavin uptake mechanisms differ among species.

The paper evaluates 4,000 Erg11 variants to determine azole resistance and fitness costs, finding 33% resistance, 88% cross-resistance, and minimal fitness cost.

The paper identifies mefloquine analogs with broad-spectrum antifungal activity, effective against Candida auris in vivo.

This study sequenced the genome of the fungal pathogen Aspergillus lentulus and predicted azole resistance genes through genomic analysis and comparative genomics.

This study identifies genetic and metabolic adaptations in pan-drug resistant Candida auris strains that enable resistance without fitness costs.

This study identifies sulfated glycosaminoglycans as targets of candidalysin, a virulence factor in C. albicans, and shows that blocking these interactions can protect epithelial cells from fungal damage.

This study examines strain variation in a non-pathogenic fungus, identifying factors linked to virulence differences across strains.

This study shows that sinefungin, a nucleoside analog, reduces the pathogenicity of C. albicans by impairing hyphal growth, biofilm formation, and adhesion to human cells without harming human cells.

This study shows how azole resistance in Candida albicans evolves through copy number variation followed by KSR1 loss of heterozygosity, resulting in a >500-fold resistance increase.

This study shows glucocorticoids increase susceptibility to Aspergillus fumigatus infection by suppressing NF-κB-mediated neutrophil control of hyphal growth in zebrafish larvae.

This study identifies synthetic peptide mimics that kill Candida albicans and synergize with caspofungin to prevent infection, showing efficacy in vitro and in vivo without resistance development.

The paper investigates how fungal cell wall remodeling in response to echinocandins leads to drug resistance by altering carbohydrate polymer assembly and physical properties.

The paper characterizes a Candida auris outbreak in Spain over five years, finding all isolates belong to clade III, share resistance mutations, and are phenotypically identical, suggesting a single origin and transmission.

This study identifies ERG251 mutations that confer azole tolerance and pleiotropic effects on stress responses and filamentation in C. albicans.

This study evaluates psoriasin's ability to inhibit Candida albicans growth on denture bases, finding it effectively eradicates fungal growth when applied to the material.

This study identifies eburicol accumulation as the mechanism by which azoles exert fungicidal effects against Aspergillus fumigatus, distinct from their action in yeasts.

This study uses Tn-seq to analyze genetic and epigenetic variation in Candida glabrata strains, revealing structural differences, resistance mechanisms, and subtelomeric chromatin accessibility.

This study identifies Erg3 and Erg6a as key enzymes in the ergosterol biosynthetic pathway of Mucor circinelloides, showing their roles in antifungal drug resistance and virulence.

This study shows that brilacidin enhances ibrexafungerp's antifungal effect against Aspergillus fumigatus, including strains resistant to caspofungin.

This study identifies ZCF13 in Candida albicans as a regulator of ribose metabolism that enhances synergistic virulence with Staphylococcus aureus during intra-abdominal infection.

This study identifies ZCF15 and ZCF26 as biofilm regulators in Candida albicans that modulate metabolic reprogramming during the planktonic-to-biofilm transition.

This study shows that aripiprazole, an atypical antipsychotic, worsens outcomes of disseminated Candida albicans infections in mice but has minimal effects on fungal growth or gene expression.