Mosquito-borne diseases and control

This paper develops modified dengue virus strains with reduced antibody-dependent enhancement risk and improved immunogenicity for a safer vaccine.

This paper identifies an A-rich linker between tandem xrRNAs in DENV2 that stabilizes their structural coupling, influencing sfRNA patterns and viral fitness.

The paper assesses future mosquito-borne disease risks in the Netherlands under different climate and land-use scenarios, finding increased outbreak sizes and growth rates for Usutu and West Nile viruses.

This study finds that vegetated urban areas increase Aedes albopictus survival and arboviral transmission risk by analyzing field data and modeling R0 for Dengue and Chikungunya in Montpellier.

This study uses a murine model to track Mayaro virus dissemination and tissue tropism, showing gestational stage affects fetal infection and suggests non-vector transmission routes.

This study identifies MYH9 as a host factor that binds to dengue virus 3'UTR, facilitating viral replication and entry, and shows inhibition reduces viral load.

The paper uses Approximate Bayesian Computation to analyze USUTU virus transmission in wildlife, showing that multiple bird species, not just blackbirds, contribute to its spread.

The paper assesses WNV dissemination in individual mosquitoes, finding that abdominal RNA detection may overestimate transmission potential and that tissue-specific testing improves accuracy.

This study tracks CD4+ T cell and IgG responses over time after yellow fever vaccination, showing peak activation at day 22 and long-term antibody persistence.

This study shows that arboviruses like CHIKV and ZIKV persist in mosquito cells by repressing viral RNA translation without overtly altering host translation, suggesting a general RNAi-independent mechanism.

This study shows plitidepsin, a marine-derived anticancer drug, has broad-spectrum antiviral activity against multiple viruses including arboviruses and DNA/RNA viruses.

This study investigates chronic ZIKV infection in adults using neuroimaging, finding no significant brain changes associated with long-term infection.

This study identifies AGPAT1 as a novel receptor for Chikungunya virus on human cells, showing its role in virus binding, uptake, and replication.

This paper develops a Dengue-Informed Neural Network (DINN) that integrates physics-informed neural networks with mechanistic models to forecast dengue incidence by inferring mosquito infection dynamics from human case data.

This study investigates how genetic, physiological, and environmental factors influence the flight and resting behavior of Aedes aegypti mosquitoes indoors.

This paper identifies prohibitin 2 (PHB2) as an orthoflavivirus restriction factor that is targeted for degradation during infection to enhance viral replication.

This study evaluates five phosphaphenalene gold(I) complexes as antivirals against ZIKV, USUV, and BAGV, finding two compounds that inhibit viral replication at low micromolar concentrations.

The paper measures mosquito attraction to humans and finds species-specific odor preferences and bacterial associations.

This study investigates the role of the PI3Kγ pathway in ZIKV-induced neuroinflammation and neuronal death, finding that its inhibition reduces viral replication and neuroinflammatory responses.

This study investigates the RNA unwinding mechanism of orthoflavivirus NS3 helicases, finding that they require translocation beyond the displaced strand and are stimulated by NS5 RdRp.

The paper tracks repeated USUV introductions and shows localized wildlife impact in urban areas due to climate and land-use factors.

This study identifies environmental and biotic factors driving the spatiotemporal distribution of Aedes albopictus in the Argentina-Brasil-Paraguay tri-border region, highlighting periurban and disturbed wild areas as key habitats.

This paper detects West Nile and Usutu viruses in environmental samples using digital PCR, providing early warnings for public health interventions.

This study compares DENV-specific memory B cell subsets in primary and secondary dengue infections, finding qualitative differences in subset frequencies and timing of peak responses.

This study uses metabolomics to distinguish Dengue and Zika virus infections in hiPSCs, identifying virus-specific metabolic signatures and pathways that regulate viral replication.

This study shows that higher salinity increases proboscis length in Culex sitiens mosquitoes, suggesting an adaptive response to saline environments and potential impacts on disease transmission.

This study develops a lethal mouse model to study Rio Negro virus pathogenesis, revealing systemic and neurological effects, immune system disruption, and neuroinflammation.

This paper develops uncertainty quantification methods to analyze stochastic models of yellow fever virus re-emergence, identifying key parameters affecting disease incidence.

This study shows that prenatal Zika virus exposure in macaques disrupts social-emotional development and visual function, independent of viral factors or maternal immunity.

This study investigates the effects of Zika virus infection on infant brain development using single-cell transcriptomics and other methods, identifying disrupted pathways and behavioral changes.