Influenza Virus Research Studies

This paper describes the generation of a mouse-adapted influenza B virus strain that gains pathogenicity in mice through mutations in non-HA/NA gene segments, independent of hemagglutinin and neuraminidase.

The paper examines influenza A virus detachment dynamics through simulations and theoretical analysis, showing detachment time depends on multiple factors and is not governed by a Poisson distribution.

This paper develops recombinant influenza A viruses expressing nanoluciferase for in vitro and in vivo tracking of viral infections, showing they replicate efficiently and can be imaged using IVIS.

This study characterizes a broad-neutralizing influenza antibody, 1122A11, showing it neutralizes multiple NA subtypes and adapts to recent glycosylation changes in H3N2 viruses.

This paper documents the spread of H5N1 HPAI in South America and Antarctica, identifies multiple introduction events, and highlights interspecies transmission and ecological risks.

This study identifies key host genes in chicken cells critical for influenza A virus replication using CRISPR-Cas9 screens, revealing conserved and species-specific factors.

This study examines how prior influenza infection memory affects CD4 T cell responses to a recombinant influenza vaccine in a mouse model, revealing shifts in T cell fate and function.

The paper conducts serological surveillance of H5 HPAI in wildlife in North-East Germany, finding seropositivity in boar and carnivores but not ruminants, indicating avian-to-mammalian spillover.

Intranasal hemagglutinin boosters after mRNA-LNP vaccination induce mucosal immunity and cross-protection against influenza A virus in mice.

This study presents a cryo-EM structure of H5N1 influenza polymerase bound to the cRNA promoter, revealing structural features essential for internal initiation of viral RNA synthesis.

This study compares the attachment patterns of H5N1 HPAI HA proteins from clade 1 and 2.3.4.4b to avian and mammalian tissues, finding comparable binding despite antigenic divergence.

This study identifies intersegment interactions in influenza A virus infected cells using LIGR-seq, showing they form in viral inclusions and are influenced by vRNP concentration and Rab11.

This paper uses explainable machine learning to identify important amino acid changes in Influenza hemagglutinin that correlate with phenotypic changes and host adaptation.

The paper benchmarks enrichment methods for sequencing low-abundance Influenza A Virus in wastewater and identifies suitable approaches for surveillance.

This study analyzes the evolutionary history and migration patterns of Influenza D virus using phylogeographic methods, finding strong links to cattle trade and land borders.

This study identifies PPM1G as a host phosphatase that regulates influenza vRNP homeostasis by modulating NP phosphorylation and autophagy.

The paper evaluates duck slurry as a matrix for detecting avian influenza viruses and characterizing their genetics, finding high sensitivity and partial genomic data.

The paper analyzes the epigenomic changes in innate immune cells after influenza virus infection and finds coordinated rewiring of the epigenetic landscape.

This study shows pigeons are not easily infected by H5N1 clade 2.3.4.4b virus and cannot transmit it to other birds or chickens.

The paper develops a machine learning model to predict zoonotic potential of avian influenza viruses using genomic data, achieving high accuracy in distinguishing zoonotic from non-zoonotic strains.

The paper reports the first detection of clade 2.3.4.4b H5N1 HPAIV in a sheep in Great Britain, highlighting the zoonotic potential and implications for interspecies transmission.

The paper shows H3N2 influenza viruses preferentially bind to tracheal ciliated cells due to specific glycan receptors.

This paper demonstrates the immunogenicity and efficacy of a computationally designed DNA vaccine against H1N1 influenza in swine and mice, showing broad neutralizing antibody responses and reduced viral shedding.

This study shows that macaques can elicit human-like broadly neutralizing antibodies against influenza HA stem regions, with similar immunogenetic and structural features.

This paper improves the expression and stability of influenza neuraminidase by grafting antigenic loops from low-expressing variants onto high-expressing scaffolds, resulting in vaccine-effective hybrid proteins.

This paper shows that influenza A virus sequesters dsRNA in infected cells to evade the innate immune response, with NS1 masking dsRNA and NEP controlling its nuclear translocation.

The paper identifies H5N1 strains in brown skuas from Antarctica, showing the virus is actively circulating there and expanding its geographic range.

This study vaccinates king penguin chicks with an mRNA vaccine against H5 HPAI and finds a persistent immune response without adverse effects.

This study investigates the factors driving the shift in dominance from H5N8 to H5N1 HPAIVs in wild birds, finding that viral pathogenicity and immune responses differ between subtypes.

The study shows cow mammary gland cells can support replication of multiple IAV strains and are susceptible to co-infection with human and avian IAVs, suggesting the udder may act as a site for viral reassortment.