Influenza Virus Research Studies

The paper shows ciliated airway cells activate influenza HA more efficiently than non-ciliated cells, and HA activation occurs intracellularly in the Golgi, affecting antiviral protease inhibitor efficacy.

This study shows that activating AMPK in mice infected with a modified H1N1 virus reduces cardiac damage by restoring mitochondrial function and improving survival.

This paper identifies a PB2-627V mutation in avian influenza viruses that enhances pandemic potential by overcoming host restriction through ANP32A proteins in both avian and mammalian hosts.

This study stabilizes the pre-fusion trimeric structures of influenza H1 and H9 hemagglutinins through stem helix mutations, enhancing thermal stability and immunogenicity.

This study quantifies the sources and sinks of influenza A virus genomic diversity in U.S. swine from 2009 to 2022, showing regional hotspots and the role of swine transport in diversity spread.

The paper analyzes antibody responses in dairy cattle to H5N1 avian influenza viruses using store-bought milk samples, finding a uniform antibody response across diverse herds.

The paper compares nasal and bronchial mucus from human airway cultures to identify components that influence influenza A virus inhibition.

The paper develops and optimizes pseudotyped viruses for influenza C and D to enable antiviral screening and sero-epidemiological studies.

This paper uses a deep learning model to predict hemagglutination inhibition titers from influenza virus sequences, enabling large-scale antigenic mapping and identifying evolutionary patterns in A(H1N1)pdm and A(H3N2) viruses.

This study identifies CLEC4E as a key driver of pro-inflammatory mDC responses in influenza using single-cell network analysis and validates its therapeutic potential in a murine model.

This paper develops a bioluminescent H5N1 influenza virus to track infection and test antiviral drugs in vitro and in vivo.

The paper uses neuraminidase-on-a-string nanoparticles to show that antigenic distance between strains influences the breadth and cross-reactivity of humoral immunity.

This study examines how mammalian- and avian-origin A(H1N1) influenza viruses interact with respiratory and gut bacteria, showing differential effects on viral infectivity when exposed to bacterial LPS.

The paper tests sheep for antibodies to H5 avian influenza virus eleven months after a nearby seabird outbreak, finding one positive case and highlighting the need to restrict livestock access to outbreak areas.

This study shows that serial passage of a human-origin H3N2 virus in swine tracheal epithelial cells selects for adaptive HA mutations that increase viral fitness in swine cells.

The paper conducts active surveillance of influenza A virus in swine farms and nurseries, revealing within-farm reassortment, cocirculation of subtypes, and human-to-swine transmission events.

This study analyzes 2.3.4.4b H5N1 viral evolution in non-human mammals to assess its potential for human adaptation and transmission.

This study identifies cytokines that enhance influenza vaccine antibody responses in human organoids and mice, showing their potential as adjuvants to improve vaccine efficacy.

The paper identifies the C-terminal domain of influenza A virus PA protein as the active center for endonuclease activity and a novel antiviral target, revealing potential drug resistance mutations and new inhibitors.

This study uses a protein language model to map influenza virus antigenicity from genotype data, revealing evolutionary patterns and improving vaccine strain selection.

This study shows that influenza A virus uses intercellular calcium waves triggered by ADP and M2 protein to spread infection, identifying a potential target for prevention.

The paper shows that lung structural cells retain an inflammatory imprint after influenza infection, enabling faster viral control upon re-challenge.

The paper identifies broad NA-reactive B cell clones and their clonal evolution, revealing molecular features and inhibitory activity against diverse influenza NAs.

This study identifies a conserved DR motif in CDR H3 of antibodies targeting the influenza virus neuraminidase active site, suggesting a common strategy for broad protection.

This study identifies a synergistic combination of Theobromine and Arainosine that effectively inhibits influenza virus channels, outperforming Oseltamivir against multiple strains.

This study identifies human antibodies that broadly inhibit influenza neuraminidase by mimicking its substrate through structural convergence and water-mediated interactions.

The paper investigates H5N1 transmission on dairy farms by sampling air, wastewater, and milk, finding infectious virus in air and wastewater, viral RNA in cow breath, and subclinical infections in cows.

This study identifies strain-specific virulence mechanisms in IAV and proposes a combination therapy using Oseltamivir and Baricitinib to reduce inflammation and improve survival in a murine model.

TreeSort detects influenza A reassortment in thousands of genomes via clock-based tests; avian H7 reassorts most, and HA, NA, MP rarely reassort in human and H5N1.