Cardiac electrophysiology and arrhythmias

Cav1.3-C-terminus Restores Electrical and Contractile Functions in hiPSC-derived Cardiomyocytes Model of Heart Failure

This study uses Cav1.3-C-terminus gene therapy to restore electrophysiological and contractile functions in hiPSC-derived cardiomyocytes with ET-1-induced heart failure.

In vivo optical induction of INaL by photoactivation of AaH-II peptide in beating heart using wireless implantable device

This paper demonstrates wireless photoactivation of a peptide to modulate cardiac excitability in vivo using an implantable device.

Human-engineered heart tissues recapitulate tissue-scale mechanisms underlying ventricular tachycardia

This paper demonstrates that human iPSC-derived engineered heart tissues can replicate tissue-scale mechanisms of ventricular tachycardia, including APD dispersion and reentry, previously only observed in intact hearts.

14-3-3 Enables β-Adrenergic Regulation of the Cardiac Sodium Channel at the Intercalated Disc

This study identifies 14-3-3 and S460 as critical for beta-adrenergic regulation of Nav1.5 at the cardiac intercalated disc, enhancing conduction velocity under sympathetic stimulation.

Calsequestrin localization at RyR2 clusters enables calcium wave propagation in ventricular myocytes

The paper develops a 3D computational model of mouse ventricular myocytes to show that calsequestrin2 (CASQ2) co-localization with RyR2 clusters is essential for reliable calcium wave propagation.

Excitation-contraction coupling plasticity is revealed upon RyR2 depletion in adult mouse ventricular myocytes

This study shows that adult mouse hearts maintain cardiac function despite significant RyR2 depletion through intrinsic ECC plasticity mechanisms.

Chronic Electrophysiology Captures Progressive Variability in DNA-Damaged Cardiac Networks

This study uses chronic electrophysiological recordings to track progressive changes in cardiac function in iPSC-CM monolayers exposed to doxorubicin, revealing spatial and temporal variability in electrical activity.