Cardiac electrophysiology and arrhythmias

Cav1.3-C-terminus Restores Electrical and Contractile Functions in hiPSC-derived Cardiomyocytes Model of Heart Failure

This study uses Cav1.3-C-terminus gene therapy to restore electrophysiological and contractile functions in hiPSC-derived cardiomyocytes with ET-1-induced heart failure.

In vivo optical induction of INaL by photoactivation of AaH-II peptide in beating heart using wireless implantable device

This paper demonstrates wireless photoactivation of a peptide to modulate cardiac excitability in vivo using an implantable device.

Human-engineered heart tissues recapitulate tissue-scale mechanisms underlying ventricular tachycardia

This paper demonstrates that human iPSC-derived engineered heart tissues can replicate tissue-scale mechanisms of ventricular tachycardia, including APD dispersion and reentry, previously only observed in intact hearts.

14-3-3 Enables β-Adrenergic Regulation of the Cardiac Sodium Channel at the Intercalated Disc

This study identifies 14-3-3 and S460 as critical for beta-adrenergic regulation of Nav1.5 at the cardiac intercalated disc, enhancing conduction velocity under sympathetic stimulation.

Calsequestrin localization at RyR2 clusters enables calcium wave propagation in ventricular myocytes

The paper develops a 3D computational model of mouse ventricular myocytes to show that calsequestrin2 (CASQ2) co-localization with RyR2 clusters is essential for reliable calcium wave propagation.

Excitation-contraction coupling plasticity is revealed upon RyR2 depletion in adult mouse ventricular myocytes

This study shows that adult mouse hearts maintain cardiac function despite significant RyR2 depletion through intrinsic ECC plasticity mechanisms.

Chronic Electrophysiology Captures Progressive Variability in DNA-Damaged Cardiac Networks

This study uses chronic electrophysiological recordings to track progressive changes in cardiac function in iPSC-CM monolayers exposed to doxorubicin, revealing spatial and temporal variability in electrical activity.

CADENCE: Open-source software for signal conditioning, feature extraction, visualization and analysis of cardiac optical mapping data

CADENCE is an open-source MATLAB-based tool for processing cardiac optical mapping data, offering end-to-end analysis with features for denoising, conduction velocity, alternans, and rotor detection across multiple species and tissue types.

Lead Exposure During Differentiation Perturbs Electrophysiological Function in iPSC Derived Cardiomyocytes in a Cell Line-Dependent Manner

This study shows that lead exposure during iPSC-derived cardiomyocyte differentiation affects electrophysiological properties in a cell line- and concentration-dependent manner, with effects persisting after exposure ends.

Nav1.5 regulates intrinsic cardiac neuronal excitability and expands the cellular basis of SCN5A channelopathies

This study shows Nav1.5 is expressed in intrinsic cardiac neurons and affects their excitability, expanding the understanding of SCN5A channelopathies beyond cardiomyocytes.

Multi-scale electrophysiological characterization of human cardioids reveals progressive maturation

This study characterizes the electrophysiological maturation of human cardioids over three weeks, showing progressive changes in membrane potential, action potential amplitude, and duration.

Metabolic Perturbation Exacerbates Sinoatrial Node Dysfunction in Heart Failure

This study identifies ceramides as mediators of mitochondrial dysfunction in sinoatrial node cells during heart failure, suggesting they as potential therapeutic targets.

Conservation and divergence of transcriptional heterogeneity in the cardiac conduction system

This study compares transcriptional heterogeneity in the cardiac conduction system across species and developmental stages using single-cell and spatial transcriptomic data.

Rad and Phospholamban are Key Drivers of the Ventricular Adrenergic Response and Stress-Induced Arrhythmia

This study identifies Rad and phospholamban as critical regulators of the adrenergic response and stress-induced arrhythmia through their role in calcium handling and cardiac function.

Endogenous subthreshold noise and PIP2 tune diastolic coherence across the intact sinoatrial node through stochastic resonance

This study shows that endogenous noise and PIP2 modulate diastolic coherence in the sinoatrial node through stochastic resonance, with coherence peaking at intermediate noise levels.

Cross-species architecture of the cardiac transverse-axial tubular system in mammals

The paper quantifies TATS ultrastructural features across eight mammalian species and finds correlations between TATS density, cardiomyocyte size, and physiological parameters like heart rate and lifespan.

A Computational Model of Oxidative Stress in a Human Ventricular Myocyte

This paper develops a computational model linking mitochondrial ROS, calcium, and electrophysiology in human ventricular myocytes, showing how ROS and calcium interact to influence cardiac function and arrhythmia risk.

PFKFB2 Gates a Relationship Between Cardiac Glycolytic Regulation and Electrophysiological Function

This paper shows that loss of PFKFB2 in cardiac cells leads to electrophysiological instability, including prolonged repolarization and ventricular tachyarrhythmia, linking glycolytic regulation to heart function.

Postmortem DNA methylation profiling uncovers signatures associated with left ventricle size

The paper identifies DNA methylation signatures in cardiac ventricles associated with left ventricle size using postmortem samples.

Electrophysiological dependent antiarrhythmic drug response in population-based models of paroxysmal atrial fibrillation

This study shows that antiarrhythmic drug efficacy in atrial fibrillation depends on patient-specific electrophysiological substrates and rotor dynamics, with drug-induced frequency reduction being a key mechanism.

Predictive value of brain 18F-FDG PET neuroimaging in a mouse model of sudden death

The paper uses 18F-FDG PET to identify metabolic signatures in a mouse model of sudden death, showing brainstem uptake can predict SUD with moderate accuracy.

Calmodulin mutation N54I causes autosomal dominant CPVT in mice

This paper shows that a single copy of the N54I calmodulin mutation in mice causes CPVT-like arrhythmias, demonstrating the functional dominance of mutant calmodulin.

Reinforcement learning discovers new mechanisms of reentry in excitable media

This paper uses reinforcement learning to discover new mechanisms of reentry in excitable media, including subthreshold stimulation strategies that induce unidirectional propagation and reentry.

Kv11.1 (hERG) Protein Interaction Networks Connect Endocytic Trafficking to Polygenic Influences on Cardiac Repolarization

This study links polygenic scores for QT interval to changes in Kv11.1 protein interactions in hiPSC-CMs, revealing connections between genetic variants and endocytic trafficking mechanisms.

Resistance to Atrial Fibrillation Domestication and Mitochondrial Dysfunction in Sheep: a potential key role of the TCA Cycle and mitochondrial redox state

This study compares mitochondrial function and TCA cycle activity in sheep resistant to atrial fibrillation (AF) versus those that develop stable AF, finding differences in redox state and energy metabolism.

RyR2-Dependent Calcium Leak Drives the Acute Cardiovascular Manifestations of Ciguatera Poisoning: implications for an emerging climate-sensitive cardiotoxic disease

This study identifies RyR2-dependent calcium leak as a mechanism underlying acute cardiovascular effects of ciguatoxin poisoning in human cardiomyocytes and rats.

iMyocyte: A Web-Based Cellular Automata Platform for Real-Time Demonstration of Cardiac Reentry

iMyocyte is a web-based platform that uses a cellular automaton model to demonstrate cardiac reentry dynamics in real time, allowing students to manipulate parameters and observe effects on wave propagation.

Node-specific amplitude alignment and finite response capacity define dynamic phase balancing in a reduced sarcomere-chain model

The paper tests dynamic phase balancing in a sarcomere model, showing that correct amplitude pairing and response time improve cancellation of length changes during hyperthermal oscillations.

Cell-Type-Resolved Transcriptomics Defines Stable and Accessible Markers of the Cardiac Purkinje Fiber in Sheep and Human Translation

Laser-capture RNA-seq of sheep Purkinje fibers yields a 331-gene enriched panel; thirteen of sixteen ranked candidates confirmed by RT-qPCR, and CNTN5 is Purkinje-enriched in sheep and human.

Cardiac microtubules mediate transverse (t)-tubule growth and homeostasis

This study shows that cardiac microtubules regulate t-tubule formation and maintenance through BIN1-CLIP-170 and dynein mechanisms, impacting Ca handling and contractile function.