Circadian rhythm and melatonin

The paper shows light adjusts the brain's circadian clock by altering molecular clockwaveforms in specific SCN regions to simulate dawn and dusk, enabling seasonal timekeeping.

The paper describes methods to detect PER2::LUCIFERASE bioluminescence rhythms in freely moving mice using a LumiCycle In Vivo system and evaluates substrate delivery methods.

This study identifies daily transcriptomic rhythms in Schistosoma mansoni, revealing rhythmic gene expression patterns and their potential relevance to parasite survival and drug targets.

This study shows NF-κB interacts with BMAL1 to regulate circadian clock function through transcriptional repression at E-box elements.

This study identifies autonomous circadian timekeeping mechanisms in the lateral geniculate nucleus (LGN) of the thalamus, showing intrinsic clock gene expression and light-entrainable oscillations in specific subregions.

The paper presents circadian proteomic and phosphoproteomic data from Arabidopsis thaliana, showing that most rhythmic phosphorylation occurs at subjective dawn and is controlled by the clock gene circuit.

The paper investigates daily electrical activity in the SCN of a diurnal mammal, finding day-night differences similar to nocturnal rodents but with a unique suppressive response.

This study investigates how temperature cycles affect circadian rhythms in Neurospora crassa, showing complex dynamics including entrainment, period-doubling, and aperiodic behavior through mathematical modeling.

This study investigates circadian rhythms in human intestinal organoids, showing circadian phase-dependent necrotic cell death responses to TcdB and identifying anti-phasic gene expression between mouse and human enteroids.

The paper introduces nCV, a method to assess circadian clock robustness in population-scale data without time labels, finding dampened oscillations in tumors.

pyActigraphy provides an open-source Python package for actigraphy data visualization and analysis, including sleep detection and rest-activity rhythm quantification.

The paper identifies rhythmic expression of Nf1 in Drosophila mushroom body neurons and shows its role in promoting daytime wakefulness through cAMP-PKA signaling.

The paper shows that the habenula clock modulates circadian variation in danger prediction, affecting anxiety-like responses to alarm pheromones in zebrafish.

The paper examines circadian regulation of visual transduction regulators in zebrafish and mice, finding rhythmic gene expression and physiological responses aligned with their diurnal/nocturnal activity patterns.

The paper shows that optogenetic activation of VIPergic SCN neurons mimics the effects of extended photoperiod on circadian rhythms and behavior.

This study shows that the SCN clock is sufficient to coordinate circadian sleep-wake cycles and improve sleep-dependent memory in clockless mice.

This study identifies INNEXIN2 as a gap junction protein that modulates the period of free-running rhythms in Drosophila melanogaster by affecting circadian pacemaker neuron function.

This paper uses machine learning to predict circadian gene expression in Arabidopsis using DNA sequence features, identifies key regulatory elements, and optimizes sampling strategies for circadian transcript prediction.

The paper uses genomic analysis to determine whether the pineal gland in Xenarthra is functional or vestigial, finding that melatonin synthesis and signaling genes are independently eroded and lost.

The paper shows that orexin A excites OPN neurons via OX2 receptor with higher responsiveness at night, and OPN firing increases during the day.

The paper uses daylight saving time as a natural experiment to study how genetic variation influences adaptation to abrupt time changes, finding differential effects based on morning or evening genetic predisposition.

The paper shows light affects mood-related behaviors in mice by inducing the clock gene Per1 in the lateral habenula, altering gene expression in the mesolimbic dopaminergic system.

This study shows clock proteins form dynamic nuclear foci that organize clock genes at the nuclear envelope to control circadian rhythms.

The paper validates a gene network model of the plant circadian clock by incorporating absolute transcription rates and testing against experimental data.

The paper shows that Venn Diagram analysis overestimates differentially rhythmic transcripts and introduces an R-package to improve accuracy in circadian rhythm studies.

This study identifies NCA-2 as a regulator of circadian period length in Neurospora by modulating intracellular calcium levels and affecting core clock component phosphorylation.

TimeCycle detects cycling transcripts in circadian time-series data using topology-based methods, showing effectiveness across various sampling schemes and data conditions.

This study shows that Per1 and Per2 are required for the daily rhythm of photoreceptor outer segment phagocytosis, with the RPE driving this process transcriptionally.

This study shows that deleting Per2 in glial cells of mice alters mood-related behaviors, reducing despair and anxiety with changes in neurotransmitter levels.