Lipid Membrane Structure and Behavior

This study uses molecular dynamics simulations to investigate how FVa binds to lipid membranes, revealing orientation changes and domain reorganization that influence its interaction with specific lipids.

This paper investigates how the cytoplasmic tail of P0 affects lipid membrane morphology and describes the production of full-length P0 for further study.

The paper shows that mammalian cells maintain a constant surface area-to-volume ratio as they grow by increasing plasma membrane folding.

This study examines how mixed lipid membrane composition affects proton transfer properties, finding that defects in the membrane structure influence proton diffusion and geminate recombination.

This study analyzes lipidome adaptation in Mycoplasma mycoides and its minimal cell JCVI-Syn3B under temperature changes, revealing universal patterns and constraints in lipid remodeling.

This study uses molecular dynamics simulations to analyze how intrinsically disordered regions of small GTPases interact with membranes, showing that lipid sequence complementarity and electrostatic interactions influence conformational dynamics and lipid sorting.

This study develops a reverse micelle fragment screening method to identify non-covalent ligands for membrane-bound GPx4, revealing ligandability at the protein-membrane interface.

This paper introduces the Freestanding-Bilayer Microscope (FBM) for single-molecule imaging of membrane proteins and benchmarks it against TIRF imaging to study ion channel dynamics.

This study shows that variance in curvature sensitivity of lipids affects membrane stiffness, with coarse-grained models showing greater softening due to clustering.

This paper identifies two archaeal enzymes involved in H-GDGT lipid modifications and demonstrates their role in producing diverse H-GDGT structures under different environmental conditions.

This study shows that reovirus capsids deform host membranes in a cholesterol-dependent manner, leading to membrane rupture and viral entry.

This study evaluates modified Nile Red dyes for super-resolution imaging of membrane packing in cells, finding differences in membrane structure between healthy and NPC1 disease fibroblasts.

This paper develops a TIR-FCS assay to measure membrane fluidity in live bacteria and finds that cold shock reduces membrane fluidity in Bacillus subtilis.

This study shows that hopanoids and sterols modulate lipid ordering differently based on phospholipid acyl chain unsaturation position, with cholesterol providing broader ordering effects than diplopterols.

This study compares the membrane scission capabilities of viral and eukaryotic proteins using mechanical models and SAXS data to analyze how lipid composition and interfacial tension affect neck size.

This study uses molecular dynamics simulations to investigate how acidic sphingomyelinase interacts with lysosomal membranes and how cation amphiphilic drugs like ebastine affect these interactions.

This paper demonstrates the manipulation of encapsulated artificial membranes using lysolipid concentrations to control their structure and properties.

This paper shows that ergosterol mediates natamycin aggregation in yeast plasma membranes, which underlies its antifungal activity and can be enhanced by sphingolipid inhibitors.

This study shows serotonin enhances vesicle association and fusion with lipid bilayers by altering their mechanical properties through water content changes.

This study uses molecular dynamics simulations to investigate how hydrophobic mismatch affects the lateral sorting of transmembrane peptides by analyzing free energy profiles and peptide orientation.

This study evaluates polarizable lipid force fields against experimental data and finds non-polarizable models often perform better despite higher computational cost.

The paper introduces OrganL, a method for simulating biomembranes with curved elements, offering improved flexibility and extensibility over existing DTS methods.

This paper develops a machine learning approach to identify phase-separated lipid domains in cryo-EM images with high accuracy.

This study uses molecular dynamics and bioinformatics to analyze structural and dynamic differences across MBOAT family members, identifying key features relevant to inhibitor design.

The paper shows lipid scrambling is a general feature of protein insertases, suggesting they may function as scramblases in membrane dynamics.

This study investigates how human STARD4 binds to membranes and transfers cholesterol, showing lipid composition and cargo influence its activity.

This study investigates how hydrophobic mismatch affects membrane protein organization using protein design, simulations, and cell-free systems, showing deformation of membranes and controlled protein assembly.

This study shows light-controlled endocytosis of biomolecular condensates in giant vesicles using photoswitchable lipids, demonstrating reversible and tunable membrane-condensate interactions.

This study shows that lipid membrane topography regulates the spatial distribution and shape of liquid protein condensates through capillary forces.

This study investigates the membrane binding dynamics of HIV-1 MA protein trimers and their interactions with anionic phospholipids using molecular dynamics simulations.