Memory and Neural Mechanisms

Disrupting selective persistent activity with electrical stimulation impairs human working memory

This study shows that disrupting selective persistent neural activity in the hippocampus and ventral temporal cortex with electrical stimulation impairs human working memory performance.

Causal necessity of human hippocampus for structure-based inference in learning

The paper demonstrates that the human hippocampus is causally necessary for structure-based inference in learning through neuroimaging, computational modeling, and stimulation experiments.

Speed modulations in grid cell information geometry

This paper develops a Gaussian Process with Kernel Regression method to analyze grid cell population activity, finding that running speed increases manifold size and noise strength, with manifold dilation having a greater impact on information coding.

Discrete Subfields and Continuous Gradients Coexist: A Multi-Scale View of Hippocampal Organization

This study investigates hippocampal organization by combining discrete subfield analysis with continuous gradients, finding that both coexist across spatial scales.

Co-allocation of distinct contextual memories within a wide time window temporal dynamics and neuronal co-reactivation during retrieval

This study examines how distinct contextual memories are linked over time and shows increased neuronal co-reactivation in the hippocampus and amygdala during retrieval of integrated memories.

Cortical GABAergic dynamics around hippocampal sharp-wave ripples

The paper maps cortical GABA dynamics around hippocampal sharp-wave ripples in mice during different brain states, revealing state-dependent regional and temporal patterns of GABA signaling.

Medial prefrontal cortex input to lateral entorhinal cortex supports both encoding and retrieval of associative recognition memory

This study shows that a direct connection from medial prefrontal cortex to lateral entorhinal cortex is critical for associative recognition memory, depending on the memory retention delay.

An Independent Coding Scheme for Distance versus Position in the Hippocampus

The paper investigates hippocampal distance coding in mice using virtual reality and electrophysiology, finding that distance coding is distinct from position coding and involves attractor dynamics.

Theanine boosts frontal theta and hippocampal beta and gamma oscillations for familiarity in object recognition

The paper investigates how theanine affects neural oscillations in mice during object recognition, finding enhanced theta and beta/gamma oscillations in specific brain regions.

Bodily perception links memory and self: a case study of an amnesic patient

The paper investigates how bodily self-consciousness affects episodic memory in a patient with hippocampal damage, showing that embodied encoding leads to stronger memory deficits.

Reconciling Flexibility and Efficiency: Medial Entorhinal Cortex Represents a Compositional Cognitive Map

This paper introduces a model for efficient model learning and planning using compositional predictive maps, showing it simulates response fields in the medial entorhinal cortex.

An amygdala-cortical circuit for encoding generalized fear memories.

This study identifies an amygdala-cortical circuit involved in encoding generalized fear memories, showing the ACC's role in extracting general threat features rather than specific contextual information.

Normative neural and physiological correlates of parent-child observational threat extinction

This study investigates normative neural and physiological correlates of parent-child observational threat extinction in adolescents using a validated paradigm and functional MRI.

Distinct goal location beta frequency dynamics in hippocampus and prefrontal cortex across learning

The paper examines beta oscillations in hippocampus and prefrontal cortex during goal location processing in rats, finding inverse relationships in their dynamics across learning.

Organization of brainwide inputs to discrete lateral septum projection populations

This study maps brainwide inputs to six discrete lateral septum projection populations, revealing unique region-dependent innervation patterns.

Fear learning sculpts functional brain connectivity at rest beyond the traditional fear network in humans

This study identifies RSFC changes beyond traditional fear networks after fear learning in humans.

Serotonin shapes the temporal window for associative fear learning

This study shows serotonin modulates the time window for fear learning by regulating neuronal activity in the ventral hippocampus.

Inhibitory neurons marked by the connectivity molecule Kirrel3 regulate memory precision

This study identifies Kirrel3-expressing inhibitory neurons that regulate memory discrimination in mice by inhibiting CA3 neuron activity during memory recall.

Representational dynamics during extinction of fear memories in the human brain

This study uses iEEG and RSA to show that human extinction learning involves context-specific neural representations in the amygdala and extinction network, with theta oscillations signaling safety and predicting fear or safety responses.

Prelimbic Cortex Activity Predicts Anxiety-Like Behavior in the Elevated Plus Maze

This study uses calcium imaging to show that higher activity in the prelimbic cortex correlates with less time spent in open arms of the Elevated Plus Maze, suggesting a role in anxiety-like behavior.

Associative coding of conditioned fear in the thalamic nucleus reuniens in rodents and humans

This study investigates the role of the nucleus reuniens in fear conditioning and extinction in rodents and humans, finding that RE activity reflects associative value and defensive behavior.

Human hippocampal ripples prioritise model-based learning

This study shows that hippocampal ripples prioritize high-value, unvisited options during model-based learning by coordinating with the lateral frontopolar cortex.

Aeon: an open-source platform to study the neural basis of ethological behaviours over naturalistic timescales

Aeon enables long-term study of ethological behaviours in mice with simultaneous brain activity recording and provides a unified data format for analysis.

Slow synaptic plasticity from the hippocampus underlies gradual mapping and fragmentation of novel spaces by grid cells

The paper shows that slow hippocampus-to-entorhinal plasticity underlies gradual grid cell map formation and fragmentation in novel environments through longitudinal imaging and modeling.

Representational drift as the consequence of ongoing memory storage

The paper shows that representational drift is an inevitable result of ongoing memory storage in neuronal circuits.

KiF1a-regulated neuronal infrastructures in sensory and prefrontal cortices essential for fear-relevant anxiety

The paper investigates how psychological stress induces fear and anxiety by altering neuronal infrastructures in sensory and prefrontal cortices, with KiF1a-mediated transport playing a critical role.

Overcoming distortion in multidimensional predictive representation

The paper investigates how multidimensional predictive learning is distorted by spurious observations and shows how semantic inductive biases can mitigate these effects in human behavior.

Disruption of hippocampal-prefrontal neural dynamics and risky decision-making in a mouse model of Alzheimer's disease

This study examines how amyloid pathology affects neural dynamics and decision-making in a mouse model of Alzheimer's disease, finding impaired risk-taking behaviors and disrupted neural connectivity.

Optimization and model averaging of histogram-based place cell firing rate maps using the point process framework

This paper optimizes histogram-based firing rate maps using the point process framework and AIC, improving spatial resolution for hippocampal place cells in rats.

A sensitivity-consistency trade-off in memory formation regulated by dentate gyrus inhibition

This study shows that PV+ interneurons in the dentate gyrus regulate the balance between sensitivity and consistency in memory formation by shifting hippocampal computation.