Memory and Neural Mechanisms

Long-Horizon associative learning as a unifying framework for statistical learning across scales

This paper introduces a unifying framework for statistical learning across temporal scales, showing a single mechanism can capture both local and higher-order patterns in data.

Flexible navigation with neuromodulated cognitive maps

This paper introduces a biologically inspired model of cognitive mapping that learns spatial representations efficiently in novel environments using neuromodulatory signals.

How visual scenes recruit spatial maps: threshold-gated activation in CA3 versus continuous integration in CA1

This study shows CA1 and CA3 in rats use different mechanisms to build spatial maps: CA1 continuously integrates landmarks, while CA3 requires a spatiotemporally integrated ensemble.

Ramping-up hippocampal ripples and their neocortical coupling support human visual short-term memory

The paper investigates how hippocampal ripple activity and its coupling with neocortical ripples support visual short-term memory maintenance in humans.

Global structure of new relational knowledge networks is represented in retrosplenial complex, and node-distance in hippocampus

The paper shows that the brain encodes network structure using distinct brain regions, with hippocampus representing shortest-path distances and retrosplenial complex representing global connectivity.

Learning stabilizes temporal activity but not neuronal selectivity in prefrontal cortex

The paper tracks prefrontal cortex neurons over time as mice learn and switch rules, finding that activity stabilizes but selectivity remains dynamic.

Recent Adversity Shapes Autonomic and Neural Threat Learning and Retrieval Under Imminent Threat: A Prospective Longitudinal Study

This study shows that recent adversity reduces autonomic threat-safety discrimination and predicts higher depression levels later, with distinct brain activation patterns linked to these effects.

Enkephalin constrains fear learning via volume transmission to the lateral amygdala

This study shows that enkephalin released in the amygdala during fear learning suppresses dopamine release, thereby constraining fear memory formation.

Unsupervised nonmotor learning in the human cerebellum

This study shows the cerebellum encodes prediction errors during nonmotor statistical learning, suggesting a domain-general role in error-based learning.

Prior experience dynamically determines differential cue weighting in the medial entorhinal cortex

The paper shows that prior experience influences how mice weigh spatial cues in the medial entorhinal cortex, with stable firing fields maintained only when previous light experience ensured coherent cue relationships.

Speed-dependent place- and time-field shifts do not require explicit temporal coding

The paper shows that speed-dependent place- and time-field shifts in hippocampal neurons can occur without explicit temporal coding, using computational models and recurrent neural networks.

Transsynaptic neural circuit mapping of ventral hippocampus motivational control systems

The paper maps transsynaptic circuits of ventral hippocampus neurons projecting to motivational control regions in rats using viral tracing methods.

PKMζ-PKC{iota}/{lambda} double-knockout demonstrates atypical PKC is crucial for the persistence of hippocampal LTP and spatial memory

The paper shows that PKC{iota}/{lambda} compensates for PKM{zeta} in maintaining hippocampal late-LTP and spatial memory when PKM{zeta} is absent.

Coexisting but dissociable place and spatial view codes in the primate hippocampus

The paper identifies coexisting position, view, and conjunctive cells in macaque hippocampus, showing dissociable spatial coding mechanisms similar to rodents.

Hippocampal ripples initiate cortical dimensionality expansion for memory retrieval

The paper shows that hippocampal ripples trigger cortical dimensionality expansion during correct memory retrieval, correlating with faster reaction times and reinstatement of target associations.

Lets talk about sex: Male and female mice show similar fear memory retention despite hippocampal activity differences during encoding and consolidation

Stress-Associated Alterations in Amygdala-Striatal Activity: A Multi-Level Analysis of Distributional, Dynamical, and Computational Signatures

The paper analyzes stress-induced changes in neural activity using distributional, dynamical, and computational approaches to characterize alterations in neural circuit dynamics without assuming a unified mechanistic explanation.

Hippocampal-midcingulate connectivity is associated with representational integration during cognitive map updating

This study investigates how hippocampal-midcingulate connectivity supports the integration of updated spatial associations during cognitive map updating.

Large-scale dimensional behavioral profiling dissociates fear memory from locomotor confounds in mice: The necessity of baseline-normalized metrics

The paper demonstrates that baseline-normalized metrics are essential for accurately interpreting fear memory in mice, showing that conventional freezing scores confound locomotor activity.

Dynamics of Dentate Gyrus Place Cells and Dentate Spikes During Spatialand Nonspatial Changes in Environments

This study examines how DG place cells and dentate spikes respond to spatial and nonspatial stimuli in familiar and novel environments, finding that nonspatial stimuli increase dentate spike activity during ethologically relevant exploration.

The nucleus of the lateral olfactory tract is required for learning odor-guided food avoidance

The paper identifies the nucleus of the lateral olfactory tract (NLOT) as critical for odor-aversion learning but not for other odor-guided behaviors or fear conditioning.

Learning-specific remodeling of the hippocampal palmitoylome

The paper investigates how spatial learning remodels the hippocampal palmitoylome in rats, identifying differential palmitoylation changes associated with learning versus general behavioral experience.

Local inhibitory topology dictates the spatial compartmentalization of hippocampal sharp-wave ripples

The paper shows that inhibitory topology determines the spatial organization of hippocampal sharp-wave ripples, while inhibitory activity governs their dynamics.

NMDA receptor-dependent Hebbian plasticity refines hippocampal spatial representations during two-dimensional navigation learning

This study shows that NMDA receptor-dependent synaptic plasticity is essential for refining hippocampal spatial representations during two-dimensional navigation learning.

A Novel Rat Spatial Inference Task Reveals Rapid Deduction of Transitive Relationships Using Schemas and Deliberation

This study introduces a novel spatial transitive inference task for rats, showing they can rapidly infer relationships using schemas and exhibit deliberation behaviors.

Light gates hormonal modulation of threat avoidance in female mice

This study shows that female mice exhibit long-term threat avoidance modulated by the estrous cycle, with opposing effects of ipRGC disruption on male and female behavior.

Human cerebellum and ventral tegmental area interact during extinction of learned fear

This study shows that the cerebellum and ventral tegmental area interact during fear extinction learning, supporting a role for prediction-error processing in this process.

Egocentric spatial scaffolds organize cortical memory engrams

The paper identifies a scaffold-engram architecture in the retrosplenial cortex that reconstructs episodic memories by reinstating self-referenced spatial representations.

Spatial and temporal representations are organized along a stable coding gradient in the medial entorhinal cortex

This study shows that the medial entorhinal cortex (MEC) is organized along a coding gradient, with neurons shifting between spatial and temporal coding based on task demands.

Human medial temporal lobe neurons link future reward coding with intertemporal choice and impulsivity

This study identifies human medial temporal lobe neurons that encode future rewards and intertemporal choices, showing reduced temporal coding in impulsive individuals.