Medical Imaging Techniques and Applications

Sources of Variability in Normative Cerebral FDG-PET imaging

The paper investigates variability in FDG-PET imaging due to scanner manufacturer, reference region, age, and sex, and generates covariate-adjusted normative data.

A multi-modal flow phantom for quantitative PET/Spectral CT

This paper develops a multi-modal flow phantom for PET and spectral CT to improve blood flow quantification by enabling tunable perfusion imaging.

Latent Gaussian Process Modeling for Dynamic PET Data: A Hierarchical Extension of the Simplified Reference Tissue Model

The paper introduces a latent Gaussian process extension of the simplified reference tissue model to capture time-varying kinetic parameters in dynamic PET data, demonstrating improved accuracy and uncertainty quantification.

FLT-PET as predictive non-invasive biomarker for neoadjuvant therapy with Wee1 and ATR inhibitors

This study uses FLT-PET to predict response to DDR inhibitors in breast cancer models, finding early sequential PET can predict efficacy while initial uptake cannot.

External validation and time-stability analysis of STARE, a blood-free quantification tool for irreversible PET tracers

The paper validates STARE, a blood-free PET quantification tool, showing high correlation with standard methods and time-stability across different scanners.

Optimized reference region and the effect on test-retest reliability and detection of Parkinson's disease with UCB-J.

This study evaluates an alternative reference region method for [11C]UCB-J to improve test-retest reliability and Parkinson's disease detection, finding reduced variability and greater effect sizes with a 10mL white matter reference region.

Evaluation of Data-based Motion Correction Techniques for High Temporal Resolution Functional PET

This study evaluates motion correction techniques for high temporal resolution fPET and finds that neither deep learning nor sliding window averaging significantly improves motion artifact mitigation compared to standard methods.

Precision measurements of brain oxygen utilization with positron emission tomography

This paper develops a model for improving precision in measuring brain oxygen utilization using [15O] tracers and PET, showing that IDIFs provide more reliable results than AIFs.

Voxel-wise regression without intensity normalizationprovides better sensitivity when identifying injuryregions after stroke in FDG-PET images

This paper introduces a regression-based method for analyzing FDG-PET images without intensity normalization, showing improved sensitivity in detecting stroke injury regions compared to existing methods.

Kinetic models for PET displacement studies

This paper develops kinetic models for PET displacement studies to estimate target occupancy from a single scan, showing good agreement with traditional methods.

caliPER: A software for blood-free parametric Patlak mapping using PET/MRI input function.

caliPER is a software that enables blood-free parametric Patlak mapping for PET/MRI by using image-derived input functions to estimate Ki and cerebral metabolic rate of glucose.

kinfitr: Reproducible PET Pharmacokinetic Modelling in R

The paper introduces kinfitr, an R package for reproducible PET pharmacokinetic modelling with 14 kinetic models and tools for data analysis.

Constant Infusion Radiotracer Administration for High Temporal Resolution Positron Emission Tomography (PET) of the Human Brain: Application to -Fluorodexoyglucose PET (FDG-PET)

The paper compares continuous infusion and bolus plus infusion radiotracer protocols for PET to improve temporal resolution, achieving 16-second glucose response mapping in the human brain.