Medical Imaging Techniques and Applications

Open-access template and database approaches for pseudo-CT generation in brain PET/MRI attenuation correction

The paper presents an open-access framework for PET attenuation correction using pseudo-CT methods with a database of MRI-CT scans, showing that UCL achieves the lowest quantification error.

Characterization and Calibration of the iQID Digital Autoradiography System for Direct Quantitative Imaging of Beta-Emitters in Tissue Samples

This paper characterizes and calibrates the iQID digital autoradiography system for quantitative imaging of 177Lu beta-emitters, showing high accuracy and resolution for small-scale features.

BrainPET Studio: An Atlas-Based, User-Friendly Desktop Tool for Quantitative PET Neuroimaging Analysis

BrainPET Studio provides a user-friendly desktop tool for quantitative PET neuroimaging analysis, validated against existing pipelines to show strong correlation in SUVR values.

Automated Long Axial Field of View PET Image Processing and Kinetic Modelling with the TurBO Toolbox

The paper introduces an automated pipeline for LAFOV PET data analysis, showing reliable parameter estimates and reduced manual effort.

MicroCT enables simultaneous longitudinal tracking of murine pancreatic cancer progression and cachexia

This paper introduces a dual-contrast microCT protocol to track tumor growth, metastasis, and cachexia in murine PDAC models over time.

Mapping Lung Cancer Ventilation Dynamics: A Pilot Mouse Study Using Functional Imaging and Lung Mechanics

This study uses functional imaging and lung mechanics to assess how tumor growth affects lung function in mice, finding significant changes in ventilation and mechanics post-tumor induction.

Generation of synthetic TSPO PET maps from structural MRI images

This paper develops a deep learning model to generate synthetic TSPO PET images from structural MRI data, achieving accurate spatial patterns and maintaining reconstruction accuracy after normalization.

A Unified Approach for Identifying PET-based Neuronal Activation and Molecular Connectivity with the functional PET toolbox

The paper introduces a unified fPET toolbox for analyzing neuronal activation and molecular connectivity, validated across cognitive tasks and radiotracers.

Kinetic modeling of 18F-PI-2620 binding in the brain using an image-derived input function with total-body PET

This study uses a total-body PET scanner to quantify tau binding and tracer kinetics in the brain using an image-derived input function and explores scan duration effects.

Optimal filtering strategies for task-specific functional PET imaging

This study evaluates filtering techniques for fPET data, finding that dNLM and MRI-MRF filters improve signal-to-noise ratio and test-retest reliability, with dNLM reducing sample size needs.

A novel method for harmonization of PET image spatial resolution without phantoms

This paper introduces a method to estimate PET image spatial resolution without phantoms, validated on clinical and ADNI datasets, showing consistent results across tracers and scanners.

A Reference Tissue Implementation of Simultaneous Multifactor Bayesian Analysis (SiMBA) of PET Time Activity Curve Data

The paper introduces a reference tissue implementation of SiMBA for PET data analysis, improving parameter estimation accuracy and enabling between-centre data harmonization.

On the analysis of functional PET (fPET)-FDG: baseline mischaracterization can introduce artifactual metabolic (de)activations

This study shows that incorrect baseline modeling in fPET-FDG can create false metabolic activity patterns, affecting GLM analyses.

Non-invasive assessment of stimulation-specific changes in cerebral glucose metabolism with functional PET

This paper introduces a method to assess cerebral glucose metabolism changes during tasks without blood sampling, using GLM beta values and percent signal change, showing strong correlation with standard CMRGlu measurements.

High-temporal resolution functional PET/MRI reveals coupling between human metabolic and hemodynamic brain response

This study uses high-temporal resolution PET/MRI to show synchronized metabolic and hemodynamic brain responses during working memory tasks.

Deciphering sources of PET signals in the tumor microenvironment of glioblastoma at cellular resolution

The paper identifies cellular sources of PET signals in glioblastoma by combining radiotracer uptake with 3D-histology and proteomics, showing tumor cells mainly contribute to TSPO enrichment while TAMs have specific PET targets.

Multivariate Analysis of PET Pharmacokinetic Parameters

The paper introduces PuMBA, a multivariate Bayesian method for PET pharmacokinetic analysis, showing improved statistical power and precision compared to univariate methods.

Source-to-Target Automatic Rotating Estimation (STARE) -- A publicly-available, blood-free quantification approach for PET tracers with irreversible kinetics: Theoretical framework and validation for FDG

The paper introduces STARE, a blood-free method for quantifying PET tracer influx rates without arterial blood sampling, validated using [18F]FDG PET data.

Monash DaCRA fPET-fMRI: A DAtaset for Comparison of Radiotracer Administration for high temporal resolution functional FDG-PET

The paper introduces an open dataset comparing three FDG-fPET radiotracer administration protocols using simultaneous BOLD-fMRI scanning.

CERMEP-IDB-MRXFDG: A database of 37 normal adult human brain FDG PET, T1 and FLAIR MRI, and CT images available for research

The paper introduces a database of 37 normal adult human brain FDG PET, T1, FLAIR MRI, and CT images for research, including acquisition parameters, processing pipelines, and demographic data.

Improved temporal resolution for mapping brain metabolism using functional PET and anatomical MRI knowledge

This paper improves the temporal resolution of functional PET by integrating anatomical MRI knowledge to reduce noise and partial volume errors in brain metabolism mapping.

Detection of Transient Neurotransmitter Response Using Personalized Neural Networks

This paper develops personalized neural networks to detect transient neurotransmitter responses in PET images, showing improved sensitivity over traditional statistical methods.

Kinfitr - an open source tool for reproducible PET modelling: validation and evaluation of test-retest reliability

This study validates kinfitr, an open-source R tool for PET kinetic modelling, showing high agreement with the commercial PMOD software in binding estimates and test-retest reliability.

Magia: Robust automated image processing and kinetic modeling toolbox for PET neuroinformatics

Magia automates PET brain data processing, producing outcome measures consistent with manual methods despite anatomical differences in reference regions.

MR-PET head motion correction based on co-registration of multi-contrast MR images

This paper introduces an automated PET motion correction method using multi-contrast MR co-registration, improving PET image quality in MR-PET scans.

Test-retest reliability and convergent validity of (R)-PK11195 outcome measures without arterial input function

This study evaluates test-retest reliability and convergent validity of (R)-[11C]PK11195 binding measures without arterial input function, finding poor reliability and weak correlations for most methods.

Accuracy and reliability of PBR28 specific binding estimated without the use of a reference region

This study evaluates the accuracy and reliability of specific binding estimates for [11C]PBR28 using the SIME method, showing good precision and reliability for VS but variability in BPND.