Bacterial biofilms and quorum sensing

This study shows flow enhances antibiotic effectiveness by overcoming bacterial defenses in Pseudomonas aeruginosa through microfluidic experiments and simulations.

This study shows how Pseudomonas aeruginosa uses local H2O2 detoxification to protect downstream cells in flow, creating spatial gradients.

This paper shows that SdiA in Klebsiella pneumoniae represses phagocytosis and intracellular survival, with mutant strains being more susceptible to phagocytosis but showing increased intracellular fitness and host cell death.

This study shows that both C4HSL and PqsE are essential for RhlR-dependent gene expression in Pseudomonas aeruginosa clinical isolates, revealing a conserved regulatory module for virulence.

This study identifies nutrient step-change and intra-species signaling as triggers for biofilm dispersion in E. faecalis, reducing antibiotic resistance in dispersed cells.

The paper identifies two compounds targeting NLPA, a lipoprotein involved in biofilm formation in Acinetobacter baumannii, showing antibacterial and biofilm inhibition activity in vitro and reduced intracellular survival in macrophages.

This study tracks the evolution of ciprofloxacin resistance in P. aeruginosa biofilms, revealing metabolic shifts and collateral sensitivity to other antibiotics.

The paper studies how resistant and sensitive E. faecalis bacteria interact under antibiotic stress, showing cooperative behavior that allows survival at high drug concentrations.

This study evaluates antibiotic susceptibility of K. pneumoniae biofilms and identifies colistin and tigecycline as most effective against biofilm biomass and metabolic activity.

This study identifies a network of c-di-GMP-binding proteins in Pseudomonas fluorescens SBW25, revealing DipA as a central hub that integrates opposing modules for biofilm formation and environmental adaptation.

This study identifies and characterizes 26 genes involved in c-di-GMP metabolism in Pantoea ananatis, revealing 14 key proteins that regulate phenotypes like motility and biofilm formation.

This study identifies a three-component logic gate involving HQNO, PqsE, and PQS biosynthesis that governs Pseudomonas aeruginosa-mediated killing of Stenotrophomonas maltophilia.

This study identifies PhoPQ as a regulator of quorum sensing in small colony variants of Pseudomonas aeruginosa, showing its role in virulence factor production and subpopulation adaptation.

This study identifies potential inhibitors of Pseudomonas aeruginosa biofilm-EPS, persistence, and quinolone signalling using mangrove-derived phytochemicals through in-silico methods.

The paper shows how spatial organization and mechanical pushing enable susceptible bacteria to survive antibiotic stress through collective behavior.

This study determines the cryo-EM structures of CqsS and its interaction with CqsA and CAI-1, revealing the molecular mechanism of quorum-sensing signal transduction in Vibrio harveyi.

This paper investigates how structural features of LuxR-type receptors determine their ligand-response mechanisms, showing that the ligand-binding domain primarily dictates associative vs. dissociative activity.

The paper investigates how microbial interactions are shaped by environmental resources versus species-produced metabolites using a controlled assay with nasal bacterial strains.

This study shows that cell motility in microbial communities disrupts clonal clustering, increases spatial intermixing, and enhances metabolic interactions and community productivity.

The paper shows that during biofilm dispersal, a subpopulation of cells forms a resilient post-dispersal biofilm community that can re-populate the niche and resist antibiotics and bacteriophages.

This study shows that polymicrobial communities can alter antibiotic susceptibilities through synergism and antagonism, and demonstrates that combining gentamicin and cephalexin can effectively clear such infections.

This study shows that charged agar surfaces alter E. coli biofilm properties by influencing curli amyloid quantity and quality, affecting structure and stability.

This study shows Pseudomonas aeruginosa uses energy-dependent T4P idling to balance dispersal and infection in fluctuating nutrient environments.

This study shows Pseudomonas aeruginosa uses different antagonistic strategies to outcompete Burkholderia cenocepacia and Staphylococcus aureus, depending on the competitor's growth rate.

The paper identifies a porphyrin-binding protein from Flavobacterium quisquiliarum that disrupts Pseudomonas aeruginosa biofilms by sequestering porphyrins and affecting iron homeostasis.

This study evaluates a triple-modality therapy combining bacteriophages, antibiotics, and antimicrobial peptides to eradicate multidrug-resistant S. marcescens biofilms in vitro.

This study shows that calprotectin affects Pseudomonas aeruginosa and Staphylococcus aureus cocultures through metal-independent mechanisms involving alkylquinolone production and quorum sensing.

The paper develops liposomal nano-sensors to measure osmotic pressure gradients in E. coli biofilms, revealing radial increases linked to biofilm structure, metabolism, and expansion.

This study shows that Pseudomonas aeruginosa uses motility to enhance phagocytosis by macrophages, while reduced motility in chronic infections helps evade engulfment, and T3SS activity enables acute immune evasion.

This study shows that type 1 fimbriae and adhesins promote microcolony formation, shielding bacteria from short-range contact-dependent weapons and maintaining phenotypic heterogeneity.