Bacterial biofilms and quorum sensing

This study identifies a convergent evolutionary mechanism in toxin detection and resistance between Pseudomonas aeruginosa and Aspergillus fumigatus, revealing shared environmental cues and enzymatic defenses.

BBSdb is an open resource that compiles biofilm-associated proteins from multiple bacteria species and omics datasets, providing tools for prediction and exploration.

This paper introduces an in vitro model of endotracheal tube biofilms that demonstrates the effectiveness of combining matrix-degrading enzymes with antimicrobials to eradicate pathogens causing ventilator-associated pneumonia.

This study shows that the LuxO-OpaR quorum-sensing cascade influences the lysis-lysogeny decision of phage VP882 based on host cell density and environment.

This study identifies SigF1 as a sigma factor regulating biofilm-promoting genes in Synechococcus elongatus through transcriptional and secretion pathways.

This study evaluates benzaldehyde derivatives as quorum sensing inhibitors in Pseudomonas aeruginosa, identifying ortho-vanillin as a competitive inhibitor of RhlR.

This study shows that androgens like testosterone promote S. aureus pathogenesis by activating the agr quorum sensing system, leading to increased virulence and skin infection.

This study reveals a populational QS mechanism in Streptococcus pneumoniae that drives antibiotic response heterogeneity through competence-induced bet-hedging.

This study shows that the horizontal expansion rate of bacterial colonies is controlled by the contact angle at the biofilm edge, validated through experimental measurements and theoretical modeling.

This paper investigates phenotypic memory in quorum sensing using theoretical models and simulations to show how past signal exposure affects future gene expression under specific conditions.

This study shows mucin glycoproteins enable surface dispersal of Staphylococcus aureus and S. epidermidis through mucin lubrication and quorum sensing-regulated surfactant peptides.

The paper identifies Dpr-mediated H2O2 resistance as critical for Streptococcus sanguinis survival in a polymicrobial CF airway model.

This study shows S. aureus biofilm produces soluble factors that activate inflammatory and immune-suppressive genes in human monocytes, suggesting a role for these factors in modulating immune responses in PJI.

This study shows that extracellular proteases and matrix molecules interact to influence biofilm formation in Bacillus subtilis, with proteases supporting biofilm even when nitrogen is freely available.

This paper identifies a pterin-responsive regulatory mechanism in Agrobacterium tumefaciens that controls biofilm formation through interactions between PruR, DcpA, and pterins.

This study shows that the bacterial QS signal 2-AA modulates immune cell bioenergetics via the PGC-1α/ERRα axis, promoting immune tolerance and pathogen persistence.

The paper evaluates antibiotic resistance and life-history traits across 20 Pseudomonas aeruginosa strains to identify adaptive strategies and inform new treatment approaches.

This study investigates how Pseudomonas aeruginosa's MvfR quorum sensing transcription factor disrupts mitochondrial function in skeletal muscle and shows that inhibiting MvfR or using mitochondrial-targeted compounds can reverse these effects.

The paper characterizes the functional metabolic diversity of Pseudomonas aeruginosa clinical isolates by analyzing genotype-phenotype correlations and genome-scale metabolic networks.

This study shows Pf phages and sputum polymers reduce antibiotic diffusion through electrostatic binding and liquid crystal formation in chronic Pseudomonas aeruginosa infections.

This study evaluates the effectiveness of intermittent electrochemical generation of H2O2 and HOCl against MRSA biofilms, showing that HOCl treatment duration and sequencing significantly impact biofilm reduction.

This study develops a label-free method to detect spatial changes in c-di-GMP levels in microbial biofilms using MALDI-MSI and applies it to three bacterial species.

This study shows that mechanical interactions and spatial constraints in confined environments limit bacterial community diversity but allow stable heterogeneous populations, even with growth advantages.

This study identifies key regulatory factors and pathways affecting swarming motility in Pseudomonas fluorescens Pf0-1, showing that Gac/Rsm pathway activation enables swarming and that Gacamide A functions as a biosurfactant.

This study shows that increased mucin and eDNA concentrations in mucus enhance Pseudomonas aeruginosa antibiotic tolerance, and establishes an in vitro model to replicate this tolerance observed in sputum.

This study investigates how operational changes affect drinking water biofilm dynamics and their susceptibility to coliform invasion, finding that mature biofilms can be infiltrated by low concentrations of Serratia fonticola.

This paper develops a four-species polymicrobial biofilm model to study interspecies interactions in cystic fibrosis lung infections and observe clinically relevant phenotypes.

This study uses secondary metabolite profiling and whole-genome sequencing to identify rare genomic traits in Pseudomonas aeruginosa isolates that affect quorum sensing and metabolite biosynthesis.

This study shows that Staphylococcus aureus cells with lower buoyant density resist antibiotics more and form biofilms at air-liquid interfaces, while higher buoyant density cells are more antibiotic-sensitive and form biofilms on liquid-solid interfaces.