Cellular transport and secretion

This study identifies the mechanisms by which Crumbs is transported and stabilized at the apical membrane in epithelial cells using Drosophila follicular epithelium.

The paper identifies 24 genes affecting luminal diameter in C. elegans excretory canals through a reverse genetic screen, revealing roles in cytoskeletal regulation and vesicle transport.

The paper shows that UNC-13L's C2A domain forms homodimers or heterodimers with RIM, and that heterodimerization regulates synaptic vesicle release probability but not priming.

This study identifies Complexin as a conserved vesicular protein that interacts with Bruchpilot's C-terminus to tether synaptic vesicles to the active zone cytomatrix in Drosophila and mouse synapses.

This study shows endophilin-A1 and A2 regulate exocytosis of neurosecretory vesicles by controlling recruitment, priming, and fusion, independent of their endocytic roles.

This study maps the membrane topology and maturation mechanism of murine Astn1 and Astn2, showing they mature via endoproteolytic cleavage by signal peptidase.

This study uses nanobodies to show that SNAP-25 and Syntaxin 1A have extra-synaptic populations in hippocampal neurons, which are not well detected by conventional antibodies.

The paper models how AD3 mutations in synaptotagmin 1's C2 domains affect Ca2+ binding pocket dynamics and explains their lethal effects through increased loop mobility and volume changes.

The paper reveals how HIV-1 Nef modulates AP-1 trimerization through cargo dynamics and phosphorylation to regulate tetherin and MHC-I downregulation.

This study shows that deletion of class II ARF causes essential tremors by impairing Nav1.6 trafficking to Purkinje cell axon initial segments.

The paper visualizes and quantifies dense core vesicle (DCV) trafficking in axons of anesthetized and awake mice, finding faster maximal speeds and lower pausing fraction in vivo compared to in vitro studies.

The paper uses spatial statistical analysis to show lysosomes have stable, distinct distributions in cells and form dynamic clusters that increase interactions with endosomes.

This study shows that disrupting Gβγ-SNARE interaction in mice leads to impaired gait, nociception, and hippocampal function, highlighting its role in GPCR-mediated presynaptic inhibition.

The paper shows that aged synaptic vesicles are inactivated by SNAP25 contamination, which inhibits exocytosis and promotes co-localization with recycling endosomes.

The paper identifies zinc storage granules in Drosophila melanogaster Malpighian tubules and links their biogenesis to specific transporters and complexes.

The paper compares synaptic dynamics between two C. elegans glutamatergic neurons, showing distinct exocytosis and retrieval properties linked to tonic and phasic release modes.

This study investigates how mutations in Membrin/GOSR2 affect dendritic growth and synaptic integrity in Drosophila models, revealing their role in neurological disorders.

This study identifies Esyt as a presynaptic ER Ca2+ sensor that enhances neurotransmission and synaptic growth in Drosophila.