Intensive Care Unit Cognitive Disorders

Mechanical Ventilation Impairs Glymphatic Function and Induces Delirium-Like Behavior in Mice

This study shows mechanical ventilation and anesthesia impair glymphatic function in mice, leading to delirium-like behavior.

Zuranolone mitigates delirium-like bispectral EEG changes, behavioral deficits, and neuroinflammation across surgical and inflammatory mouse models and age groups

Clinical risk factors of intensive care unit acquired weakness predicted by human muscle microtissue response to humoral factors

This study uses human muscle microtissues to show that humoral factors from ICU patients predict clinical risk factors of ICUAW and CIM.

Glial Contribution to the Pathogenesis of Post-Operative Delirium Revealed by Multi-omic Analysis of Brain Tissue from Neurosurgery Patients

This study uses multi-omic analysis of brain tissue from POD patients to show glial cell contributions to pathogenesis, identifying epigenetic and transcriptomic changes in microglia and astrocytes.

An immune signature of postoperative cognitive decline in elderly patients

This study identifies an immune signature predicting postoperative cognitive decline using single-cell and plasma proteomic data from elderly patients.

Epigenetics of post-operative delirium: A genome-wide DNA methylation study of neurosurgery patients

This study identifies DNA methylation changes associated with post-operative delirium in neurosurgery patients using genome-wide analysis of blood samples.