Intensive Care Unit Cognitive Disorders

Mechanical Ventilation Impairs Glymphatic Function and Induces Delirium-Like Behavior in Mice

This study shows mechanical ventilation and anesthesia impair glymphatic function in mice, leading to delirium-like behavior.

Zuranolone mitigates delirium-like bispectral EEG changes, behavioral deficits, and neuroinflammation across surgical and inflammatory mouse models and age groups

Dissecting the genetic and proteomic risk factors for delirium

This study identifies genetic and proteomic risk factors for delirium, highlighting APOE as a key gene and novel biomarkers, and suggests potential drug targets.

Clinical risk factors of intensive care unit acquired weakness predicted by human muscle microtissue response to humoral factors

This study uses human muscle microtissues to show that humoral factors from ICU patients predict clinical risk factors of ICUAW and CIM.

The age-related susceptibility to postoperative delirium quantified by bispectral electroencephalography (BSEEG) correlates with postoperative delirium-like behavior in mice

This study correlates BSEEG scores with delirium-like behavior in mice, showing age-related differences in the relationship between BSEEG and behavioral outcomes.

Glial Contribution to the Pathogenesis of Post-Operative Delirium Revealed by Multi-omic Analysis of Brain Tissue from Neurosurgery Patients

This study uses multi-omic analysis of brain tissue from POD patients to show glial cell contributions to pathogenesis, identifying epigenetic and transcriptomic changes in microglia and astrocytes.

LPS-induced delirium-like behavior and microglial activation in mice correlate with bispectral electroencephalography (BSEEG)

This study validates the use of BSEEG in an LPS-induced mouse model of delirium, showing its correlation with behavioral changes and microglial activation.

The bispectral EEG (BSEEG) method quantifies post-operative delirium-like states in young and aged mice after head mount implantation surgery

This study validates the BSEEG method for quantifying post-operative delirium-like states in mice, showing age-related differences in recovery.

An immune signature of postoperative cognitive decline in elderly patients

This study identifies an immune signature predicting postoperative cognitive decline using single-cell and plasma proteomic data from elderly patients.

Conserved YKL-40 changes in mice and humans after postoperative delirium.

This study identifies conserved YKL-40 changes in mice and humans after postoperative delirium, linking systemic and CNS inflammation to neuroimmune interactions.

Epigenetics of post-operative delirium: A genome-wide DNA methylation study of neurosurgery patients

This study identifies DNA methylation changes associated with post-operative delirium in neurosurgery patients using genome-wide analysis of blood samples.

Potential involvement of monoamine oxidase activity in SARS-COV2 infection and delirium onset

The paper investigates the role of monoamine oxidase B in delirium onset during SARS-CoV-2 infection using metabolomic profiling and computational analysis.

Epigenetics biomarkers of delirium: immune response, inflammatory response and cholinergic synaptic involvement evidenced by genome-wide DNA methylation analysis of delirious inpatients

The paper identifies DNA methylation differences in blood between delirium patients and non-delirium controls, highlighting immune response and cholinergic synapse pathways.

Investigating speech and language impairments in delirium: a preliminary case-control study

This study compares language abilities in delirium, dementia, and cognitively unimpaired patients, finding impairments in speech production and comprehension in delirium.