Ultrasound and Hyperthermia Applications

Focal Neurostimulation of Calcium Signaling and Dopamine Release in Human Dopaminergic Neurons Using Megahertz-range Single-Pulse Focused Ultrasound

This study shows that single-pulse megahertz-range focused ultrasound can evoke calcium signaling and dopamine release in cultured human dopaminergic neurons.

Ultrasound-Mediated Gene Therapy in Alzheimer's Disease Validated through In Vivo PET Imaging

This study validates ultrasound-mediated gene therapy for Alzheimer's disease using PET imaging to track AAV delivery and therapeutic effects.

Microbubble Backscattering Intensity Improves the Sensitivity of Three-dimensional (3D) Functional Ultrasound Localization Microscopy (fULM)

This paper introduces backscattering fULM (B-fULM) to improve 3D functional ultrasound imaging sensitivity by integrating microbubble amplitude with count-based localization.

Enhanced delivery of lipid nanoparticle-based immunotherapy by modulating the tumor tissue stiffness using ultrasound-activated nanobubbles

This study shows that ultrasound-activated nanobubbles reduce tumor stiffness and enhance lipid nanoparticle delivery and immunotherapy efficacy.

Unilateral online ultrasound stimulation of early visual cortex suppresses responses to contralateral visual stimuli

The paper shows that unilateral TUS of early visual cortex suppresses contralateral visual responses, indicating online neuromodulatory effects and dose-dependent suppression.

Quantification of microbubble-induced streaming across ultrasound frequencies using particle image velocimetry

This study quantifies microbubble-induced streaming across ultrasound frequencies using PIV, finding stronger streaming at lower frequencies than expected.

Ultrasound-enhanced retinal delivery of engineered viral vectors

This study evaluates FUS-BRBO for retinal gene delivery, showing AAV.FUS.3 achieves 2.1-fold and 19.5-fold higher transduction than AAV9 in insonated and uninsonated retinas, respectively.

In vivo tracking of CAR-T cells in tumors via nanobubble-based contrastenhanced ultrasound

This paper demonstrates a method to track CAR-T cells in vivo using nanobubble-based contrast-enhanced ultrasound, showing effective visualization in both tumor-bearing and non-tumor-bearing mice.

PEI-Coated Microbubble Attachment to Neutrophils: Potential for Radiation Force Assisted Delivery into Tissue

This paper demonstrates the attachment of PEI-coated microbubbles to neutrophils using click chemistry and electrostatic interactions, enabling ultrasound-responsive targeted delivery without compromising cell viability or migration.

Impact of Focused Ultrasound on the Cellular Network of Liver Tissue: A New Perspective for Thermal Lesion Detection

This paper shows that HIFU treatment causes anisotropic changes in liver tissue detectable via backscattering coefficient, linking energy delivery to tissue response for thermal lesion monitoring.

Nanobubble based sonobiopsy reveals circulating protein signatures of BBB opening and glioblastoma

This study uses nanobubble-mediated proteomic sonobiopsy to identify molecular signatures of BBB opening and glioblastoma in mice, distinguishing tumor-specific biomarkers from those caused by BBB disruption.

Noninvasive enrichment of circulating tumor biomarkers in a mouse model of diffuse midline glioma using focused ultrasound

This study shows that focused ultrasound with microbubbles can increase circulating tumor biomarkers in blood and CSF of a mouse DMG model, with enrichment varying by source, analyte type, and marker.

Non-invasive Ultrasonic Neuromodulation of the Human Nucleus Accumbens Impacts Reward Sensitivity

This study shows that non-invasive ultrasound stimulation of the human nucleus accumbens affects reward processing and learning, similar to deep brain stimulation.

Repeated blood-brain barrier opening using low-intensity pulsed ultrasound mitigates amyloid pathology

This study shows that repeated BBB opening using LIPU reduces amyloid pathology in a mouse model of Alzheimer's disease.

Deep cerebellar tFUS engages cortical circuits via convergent local and sensory-driven mechanisms

This study investigates how tFUS affects cortical circuits through direct and indirect mechanisms by targeting different brain regions in rats.

Transcranial ultrasound neuromodulation of a human white matter tract

This study shows that transcranial ultrasound can specifically modulate motor neurophysiology in the human corticospinal tract, with effects dependent on ultrasound pressure and white matter microstructure.

Ultrasonic rewarming of cryopreserved alginate encapsulated liver spheroids

This study compares ultrasonic rewarming with a water bath for cryopreserved liver spheroids, finding faster rewarming times but mixed effects on viability.

Frequency-Dependent Modulation of the Prefrontal Cortex by Low-Intensity Focused Ultrasound: Impact on Mesolimbic Dopamine Signaling

This study shows that low-intensity focused ultrasound (LIFU) with specific frequency patterns can modulate dopamine release and astrocytic activity in the nucleus accumbens, with effects dependent on frequency and sex.

Ultrasound-induced Particle Dynamics in Pathological Vascular Vortices

The paper investigates how ultrasound affects microparticle behavior in disturbed vascular vortices, showing microbubbles self-assemble and anchor to vessel walls, suggesting a new therapeutic strategy.

VEGFR2 blockade converts thermally ablative focused ultrasound into a potent driver of T cell-dependent anti-tumor immunity

This study combines thermally ablative focused ultrasound with VEGFR2 blockade to enhance T cell-dependent anti-tumor immunity and synergize with checkpoint inhibition.

Wearable Focused Ultrasound Neuromodulation and Electrophysiological Recording Patch for REM Sleep Enhancement

This paper introduces a wearable patch for non-invasive ultrasound neuromodulation and sleep recording, showing increased REM sleep duration and reduced latency in human subjects.

A multimodal brain phantom for noninvasive neuromodulation

This paper introduces a low-cost brain phantom for testing noninvasive neuromodulation techniques, validated for LIFU and tDCS with accurate biophysical properties.

Understanding the high-order network plasticity mechanisms of ultrasound neuromodulation

This paper develops a whole-brain model to study how transcranial ultrasound stimulation (TUS) induces functional changes in the brain, identifying two mechanisms that predict plasticity-driven effects.

Modulating Peripheral Neural Activity: Prolonged Low-Intensity Ultrasound for Controlled Excitation and Suppression in Rat Sciatic Nerve

This study investigates how varying ultrasound parameters affect neural activity in rat sciatic nerves, finding that cumulative energy exposure determines excitation or suppression of motor responses.

Deep Brain Ultrasound Augments Human Attention

This study uses deep brain ultrasound to modulate visual attention by stimulating subcortical structures, showing site-specific effects on reaction time and search efficiency.

Neurodegeneration Associated with Repeated High-Frequency Transcranial Focused Ultrasound

This study shows that repeated high-frequency tFUS exposure in non-human primates leads to neurodegeneration in stimulated and functionally connected brain regions, despite no behavioral disruption.

Early micro and nanoscopic responses of microglia to blood-brain barrier modulation by transcranial-focused ultrasound

This study examines early microglial responses to FUS-induced BBB modulation, finding no significant density changes but increased cell elongation and altered synaptic interactions.

Transcranial ultrasound stimulation modulates neuronal membrane potentials across broad timescales in the awake mammalian brain

This study shows that transcranial ultrasound stimulation modulates neuronal membrane potentials in awake mice, with rapid depolarizations and entrainment effects.

Ultrasound system for precise neuromodulation of human deep brain circuits

This paper introduces an advanced transcranial ultrasound system that precisely modulates deep brain circuits with high spatial resolution and specificity.

PET imaging for non-invasive monitoring of 89Zr-Talidox delivery to the brain following focused ultrasound-mediated blood-brain barrier opening

This study uses PET imaging to monitor Talidox delivery to the brain after focused ultrasound opens the blood-brain barrier, showing a 14-fold increase in brain uptake.