Ultrasound and Hyperthermia Applications

Low-intensity focused ultrasound enables temporal modulation of human midbrain organoid differentiation

This paper demonstrates that low-intensity focused ultrasound can modulate midbrain organoid differentiation by promoting dopaminergic progenitor cells and delaying terminal differentiation without causing cellular damage.

Machine learning-based optimization of a single-element transcranial focused ultrasound transducer for deep brain neuromodulation in mice

This paper optimizes single-element transcranial focused ultrasound transducers for deep brain neuromodulation in mice using machine learning and simulation.

Passive Acoustic Dynamic Differentiation and Mapping: A Time-Domain Passive Cavitation Localization and Classification Approach

This paper introduces PADAM, a time-domain passive cavitation imaging method that improves resolution and reduces artifacts compared to existing methods, enabling better cavitation monitoring and control in FUS therapy.

A Precision Ultrasound-Localized Sonoporation-Equipment (PULSE) Enabling Intratumoral Delivery for Cancer Immunotherapy

The paper introduces PULSE, a device for targeted ultrasound-mediated delivery of drugs and genes in tumors, showing improved transfection and perfusion in vitro and phantom tests.

Development of ultrasound molecular contrast agents by site-specific conjugation of gas vesicles to antibodies

This study develops site-specific antibody-gas vesicle conjugates as durable cancer-targeting ultrasound contrast agents, validated through testing on cancer cell lines and tumor-bearing mouse cells.

Real-time Color Flow Mapping of Ultrasound Microrobots

This paper introduces a method for real-time visualization of microrobots using Color Flow Mapping ultrasound, enabling localization and activation of bubble-based microrobots.

Combination of cycling hyperthermia and Echinacoside creates synergistic curing effect on pancreatic cancer PANC-1 cells

The paper shows that combining Echinacoside with thermal-cycling hyperthermia enhances the anti-cancer effect on PANC-1 cells by targeting multiple apoptotic pathways.

Low-frequency ultrasound-mediated blood-brain barrier opening enables non-invasive lipid nanoparticle RNA delivery to glioblastoma

This paper demonstrates that low-frequency ultrasound can safely open the blood-brain barrier to deliver lipid nanoparticles (LNPs) containing RNA to glioblastoma tumors in mice.

Ultrasound imaging of in situ transcriptional activity in opaque tissue

This paper develops a system to image in situ transcriptional activity in opaque tissues using ultrasound and acoustic reporter genes, demonstrating long-term tracking of gene expression in the mouse brain.

Focal neurostimulation of propagating calcium waves in human neural cells using megahertz-range single-pulse focused ultrasound

This study uses megahertz-range single-pulse focused ultrasound to induce focal calcium waves in human neural cells, showing that radiation force at >5 MHz provides safer, more predictable stimulation than cavitation.

A Wearable Spiral Ultrasound Patch for Focused Ultrasound Peripheral Neuromodulation of Diabetic Neuropathic Pain

This paper introduces a wearable spiral ultrasound patch for non-invasive treatment of diabetic neuropathic pain, showing significant pain relief and improved nerve conduction in a rat model.

Low-Intensity Ultrasound Lysis of Amyloid Microclots in a Lab-on-Chip Model

This study evaluates low-intensity ultrasound's effect on amyloid microclot lysis, showing significant clot reduction at 150 kHz and enhanced lysis with microbubbles and rtPA.

Modulating Brain Perfusion, Functional Connectivity, and Metabolite Patterns through Theta Burst Transcranial Focused Ultrasound Stimulation

This study examines the effects of theta-burst transcranial focused ultrasound on cerebral blood flow, functional connectivity, and metabolite levels in the primary motor cortex using multimodal neuroimaging.

High-resolution imaging reveals a cascade of interconnected cellular bioeffects differentiating the long-term fates of sonoporated cells

This study uses high-resolution imaging to compare the spatiotemporal biological responses of reversibly and irreversibly sonoporated cells, revealing distinct cellular bioeffects that determine their long-term fates.

A bottom-up approach to understanding ultrasound mediated blood-brain barrier opening using long and short pulses

This study compares long and short pulse ultrasound effects on BBB opening, finding long pulses increase drug delivery but cause damage, while short pulses are safer and more uniform.

Parameter optimisation for mitigating somatosensory confounds during transcranial ultrasonic stimulation

This study identifies strategies to mitigate somatosensory confounds during transcranial ultrasonic stimulation by optimizing parameters such as pulse shaping and transducer settings.

Bioadhesive Hydrogel-Coupled and Miniaturized Ultrasound Transducer System for Long-Term, Wearable Neuromodulation

This paper develops a wearable ultrasound device with bioadhesive hydrogel for long-term neuromodulation, demonstrating its effectiveness in suppressing somatosensory responses over 28 days.

Noninvasive Control of Seizure Threshold with Acoustically Targeted Chemogenetics

This study uses acoustically targeted chemogenetics to non-invasively increase seizure threshold in mice by inhibiting hippocampal pyramidal neurons.

Single cell level analysis of ATP release kinetics and cell fate following ultrasound targeted microbubble cavitation using microscopy techniques

This study quantifies ATP release and cell fate changes after ultrasound-targeted microbubble cavitation using microscopy and microfluidics, showing dead cells release more ATP than sonoporated cells.

Focused ultrasound to the bilateral thalamus causally modulates human cognitive attention in a frequency- and intensity-dependent manner

This study shows that focused ultrasound stimulation of the thalamus can enhance cognitive attention in humans, with effects dependent on frequency and intensity.

Low intensity pulsed ultrasound activates excitatory synaptic networks in cultured hippocampal neurons

This study shows that low-intensity pulsed ultrasound enhances excitatory synaptic transmission in high-density hippocampal neuron cultures by increasing EPSC frequency and amplitude.

Mechanical Artifacts During Transcranial Focused Ultrasound Mimic Biologically Evoked Responses

The paper identifies mechanical artifacts in tFUS-induced LFP signals in anesthetized rats, showing they mimic genuine neural responses and are artifact-driven.

Ultrasound-actuated drug delivery with acoustic percolation switches

This paper introduces a drug delivery system using ultrasound to trigger release from hydrogels containing gas vesicles, demonstrating targeted delivery in a rat colitis model.

Looking for the optimal pathway to stimulate hippocampus in human participants using transcranial ultrasound stimulation (TUS): a simulation study

This study simulates low-intensity transcranial ultrasound stimulation (TUS) to identify optimal pathways for targeting the hippocampus in humans.

Optimization of MR-ARFI for Human Transcranial Focused Ultrasound

This study optimizes MR-ARFI for human transcranial focused ultrasound to reduce exposure and improve motion robustness, demonstrating its potential for guiding neural therapeutics.

Data-driven feedback augments ultrasound nanotheranostics in brain tumors

This study uses machine learning to enhance focused ultrasound for BBB opening, improving nanoparticle delivery and tumor DNA detection in brain tumors.

Improving Targeting Specificity of Transcranial Focused Ultrasound in Humans Using a Random Array Transducer: A k-Wave Simulation Study

This study improves tFUS targeting specificity using a phase-reversal correction method with a random array transducer, showing significant increases in focal overlap and energy delivery.

Closed-loop sonothermogenetic control of CAR T cells for metronomic brain cancer therapy

This study demonstrates closed-loop sonothermogenetic control of CAR T cells to achieve metronomic activation in brain tumors without harming healthy tissue.

Selective manipulation of excitatory and inhibitory neurons in top-down and bottom-up visual pathways using ultrasound stimulation

The paper demonstrates that specific pulse repetition frequencies of ultrasound stimulation can selectively modulate excitatory and inhibitory neurons in top-down and bottom-up visual pathways in rodents.

Cerebellum-Targeted Transcranial Focused Ultrasound Stimulation Modulates Hippocampus Neural Activities

This study shows that cerebellum-targeted tFUS at 10kHz modulates hippocampal neural activity through cerebellum cortex, not deep nuclei, via altered neurodynamic interactions.