Ultrasound and Hyperthermia Applications

This study uses megahertz-range single-pulse focused ultrasound to induce focal calcium waves in human neural cells, showing that radiation force at >5 MHz provides safer, more predictable stimulation than cavitation.

This study examines the effects of theta-burst transcranial focused ultrasound on cerebral blood flow, functional connectivity, and metabolite levels in the primary motor cortex using multimodal neuroimaging.

This study compares long and short pulse ultrasound effects on BBB opening, finding long pulses increase drug delivery but cause damage, while short pulses are safer and more uniform.

This study uses acoustically targeted chemogenetics to non-invasively increase seizure threshold in mice by inhibiting hippocampal pyramidal neurons.

This study shows that focused ultrasound stimulation of the thalamus can enhance cognitive attention in humans, with effects dependent on frequency and intensity.

This study uses machine learning to enhance focused ultrasound for BBB opening, improving nanoparticle delivery and tumor DNA detection in brain tumors.

This study improves tFUS targeting specificity using a phase-reversal correction method with a random array transducer, showing significant increases in focal overlap and energy delivery.

This study demonstrates closed-loop sonothermogenetic control of CAR T cells to achieve metronomic activation in brain tumors without harming healthy tissue.

This study shows that cerebellum-targeted tFUS at 10kHz modulates hippocampal neural activity through cerebellum cortex, not deep nuclei, via altered neurodynamic interactions.

This study uses ultrasound to modulate calcium influx in splenic immunocytes, enhancing antitumor immunity and significantly suppressing hepatocellular carcinoma growth.

This study shows that transcranial ultrasound stimulation of the anterior temporal lobe improves semantic memory by altering brain structure, chemistry, and function.

This study shows ultrasound directly activates sparse neurons in deafened mice, modulates visual circuits, and confirms direct mechanical effects independent of auditory input.

This study investigates how low-frequency focused ultrasound affects astrocyte and neuronal calcium dynamics in mouse cortex, finding state-dependent effects with greater astrocytic response in awake mice.

Portable therapeutic ultrasound enhanced AAV9 delivery to the brain in mice and rhesus macaques compared to systemic injection alone.

This paper introduces a transparent ultrasound transducer cranial window for integrating ultrasound neuromodulation and optical neuroimaging in awake mice, showing increased cerebral blood flow and hemoglobin with stimulation.

The paper introduces an acoustic pH sensor called pHonon for deep tissue imaging of cellular acidification using nonlinear ultrasound.

This study investigates how spinal cord ultrasound stimulation affects corticospinal excitability using varying acoustic parameters and finds that high intensity and high PRF reduce motor-evoked potential amplitudes.

This paper introduces a new microbubble design that enables controlled assembly and acoustic steering for biomedical applications.

This paper develops a non-invasive ultrasound-based method to track cell-based therapies using acoustic reporter genes in primary mammalian cells.

This study uses TUS and calcium imaging in awake mice to show focal effects on cortical activity and proposes a circuit model explaining these effects.

This paper develops a system using ultrasound to remotely stimulate gene expression in tumors, enabling precise CAR T cell activation for immunotherapy.

This study investigates the effects of repeated low-intensity focused ultrasound (LiFUS) with microbubbles on microglial profiles in a rat model of Alzheimer's disease, finding both short-term and long-term changes in inflammation and amyloid levels.

This study examines how different parameters of low-intensity focused ultrasound affect human brain activity, finding inhibition in some cases and no excitation.

The paper analyzes nanobubble ultrasound contrast agent kinetics and angiogenic signaling in head and neck cancer using pixel clustering and proteomics.

This study evaluates the feasibility of using focused ultrasound to deliver an anti-alpha-synuclein antibody to Parkinson's disease mouse models, showing successful BBB opening and antibody delivery.

The paper uses single-cell RNA sequencing to identify GINIP-expressing neurons as the main targets of focused ultrasound in DRG neurons.

This study shows that tFUS selectively activates excitatory neurons in the cortico-thalamo-cortical pathway, modulating feedforward and feedback loops between brain regions.

This study investigates cell-type specific effects of tFUS in awake rats, finding that PRF and DC sensitivity persists despite some differences compared to anesthetized conditions.

This study shows that mild hyperthermia enhances liposomal doxorubicin uptake and CD8+ T cell infiltration in 4T1 tumors.