Advanced Neuroimaging Techniques and Applications

Advantages of Multi-shell Diffusion Models for Studies of Brain Development in Youth

This study evaluates DTI, NODDI, and MAPL in youth to assess their associations with age and motion, finding that multi-shell models offer advantages for neurodevelopmental studies despite motion sensitivity.

Histological validation of per-bundle water diffusion metrics within a region of fiber crossing following axonal degeneration

The paper validates per-bundle dMRI metrics in a fiber crossing region using histological data from axonally degenerated optic nerves in rats.

Charting shared developmental trajectories of cortical thickness and structural connectivity in childhood and adolescence

This study uses non-negative matrix factorisation to identify cortical regions co-varying with connectivity subnetworks in children and adolescents, finding age-related changes in cortical thickness and connectivity.

Joint modelling of diffusion MRI and microscopy

This paper proposes a joint model for diffusion MRI and microscopy data to improve microstructural analysis by combining complementary information from both modalities.

A framework for spatial normalization and voxelwise analysis of diffusion propagators in multiple MAP-MRI data sets

This paper introduces a framework for spatial normalization and voxelwise analysis of diffusion propagators across multiple MAP-MRI datasets, enabling detection of subtle microstructural changes.

Reproducible Tract Profiles (RTP): from diffusion MRI acquisition to publication

The paper introduces a system for reproducible tractography using diffusion MRI data through a cloud-based platform and containerized tools.

White matter microstructure and its relation to longitudinal measures of depressive symptoms in mid-late life

The paper examines the relationship between white matter microstructure and longitudinal depressive symptoms in mid-late life, finding significant associations across different measures of symptomatology.

Dimensionality Reduction of Diffusion MRI Measures for Improved Tractometry of the Human Brain

This paper reduces the dimensionality of diffusion MRI measures to identify biologically interpretable components that capture age-related changes in white matter microstructure.

Using the residual bootstrap to quantify uncertainty in mean apparent propagator MRI

This paper quantifies uncertainty in MAP-MRI derived metrics using residual bootstrap methods, showing that resampling within each shell generates larger uncertainty than using all shells.

Reducing variability in along-tract analysis with diffusion profile realignment

This paper introduces diffusion profile realignment to reduce variability in along-tract dMRI analysis by improving alignment across subjects, enhancing detection of regional changes.

Tractography Reproducibility Challenge with Empirical Data (TraCED): The 2017 ISMRM Diffusion Study Group Challenge

The paper evaluates tractography reproducibility using empirical data from a single healthy volunteer scanned on two scanners, finding high consistency among top algorithms but variability due to tract volume containment.

On the interpretation of tractography-based parcellations

This study shows that diffusion tractography-based parcellations of subcortical structures can be obtained without internal anisotropy, suggesting caution in interpreting such results.

Quantitative modeling links in vivo microstructural and macrofunctional organization of human and macaque insular cortex, and predicts cognitive control abilities

The paper uses diffusion MRI to analyze microstructural and macrofunctional organization of the human and macaque insula, linking these features to cognitive control abilities.

Towards an optimised processing pipeline for diffusion MRI data: Effects of artefact corrections on diffusion metrics and their age associations in UK Biobank

The paper evaluates different diffusion MRI processing steps in UK Biobank data to suggest an optimised pipeline that improves reliability and reduces variability in diffusion metrics and their age associations.

Optimization of graph construction can significantly increase the power of structural brain network studies

This study evaluates 20 graph construction schemes for structural brain networks, finding that scheme choice significantly affects reproducibility and statistical power.

Viewing pictures triggers rapid morphological enlargement in the human visual cortex

The paper shows that viewing pictures rapidly increases gray matter volume and cortical thickness in the visual cortex within 263 seconds.

Fast quantification of uncertainty in non-linear diffusion MRI models for artifact detection and more power in group studies

This paper introduces a method to quantify uncertainty in diffusion MRI models, showing it improves artifact detection and statistical power in group studies.

Microstructural and Functional Gradients are Increasingly Dissociated in Transmodal Cortices

The paper identifies a dissociation between microstructural and functional gradients in transmodal brain networks using histological and MRI data.

Developmental changes in connectivity between the amygdala subnuclei and occipitotemporal cortex

The paper examines developmental changes in amygdala connectivity to occipitotemporal cortex in humans, finding similar adult-like patterns in children and neonates with refinement over development.

Reducing false positives in tractography with microstructural and anatomical priors

The paper improves tractography by reducing false positives using anatomical priors and group-sparsity regularization in a convex optimization framework.

Evaluating the performance of 3-tissue constrained spherical deconvolution pipelines for within-tumor tractography

This study evaluates 3-tissue constrained spherical deconvolution pipelines for within-tumor tractography, finding that single-shell 3-tissue CSD enables tractography in infiltrating gliomas without increasing dMRI acquisition requirements.

In vivo microstructural heterogeneity of white matter lesions in Alzheimer’s disease using tissue compositional analysis of diffusion MRI data

This study uses diffusion MRI to analyze microstructural heterogeneity in white matter lesions of Alzheimer’s disease patients, revealing differences in tissue composition between lesion types and their proximity to ventricles.

Tractostorm: Rater reproducibility assessment in tractography dissection of the pyramidal tract

This study assesses the reproducibility of manual segmentation of the pyramidal tract in diffusion MRI tractography across experts and non-experts, finding voxel-wise measures more reproducible than streamline-wise ones.

Myelination of major white matter tracts continues beyond childhood -- combining tractography and myelin water imaging

This study combines myelin water imaging and diffusion tensor tractography to show that myelination continues beyond late childhood in most major white matter tracts.

Euclidean distance as a measure to distinguish ventral and dorsal white matter connectivity in the human brain

The paper shows that ventral white matter pathways have longer Euclidean distances than dorsal pathways between parietal and inferior frontal cortex, suggesting Euclidean distance could be a simple measure for distinguishing these pathways in fMRI studies.

The spatial correspondence and genetic influence of inter-hemispheric connectivity with white matter microstructure

The paper uses MRI data to show that white matter microstructure predicts functional connectivity between brain regions, with genetic variants linked to this relationship.

Automated 3D Axonal Morphometry of White Matter

The paper develops an automated 3D segmentation pipeline for axonal morphology analysis in rat white matter and finds reduced axonal diameter in chronic brain injury.

Global and regional white matter development in early childhood

This study characterizes white matter development in early childhood, showing increases in fractional anisotropy and decreases in mean diffusivity, with sex differences and significant changes in occipital and limbic connections.

Histologically derived fiber response functions for diffusion MRI vary across white matter fibers - an ex vivo validation study in the squirrel monkey brain

This study derives histologically-derived fiber response functions for diffusion MRI in squirrel monkey brains and shows they vary across brain regions and subjects, affecting FOD reconstruction and tractography.

Large-scale GWAS reveals genetic architecture of brain white matter microstructure and genetic overlap with cognitive and mental health traits (n=17,706)