Advanced Neuroimaging Techniques and Applications

Variations in perfusion detectable in advance of microstructure in white matter aging

This study examines the relationship between perfusion and white matter microstructure in aging, finding that arterial transit time declines before microstructural changes and varies by tract and sex.

TRAMFIX: TRavelling Across Melbourne for FIXel-based analysis (a reproducibility study)

TRAMFIX evaluates the reproducibility of fixel-based analysis across multiple MRI scanners and finds high reliability for whole-brain and tract-level metrics, with some variability at the fixel level.

Generating brain-wide connectome using synthetic axonal morphologies

The paper generates whole-brain connectivity by predicting detailed axonal morphologies from sparse data, enabling in silico experimentation of large brain regions.

Linking White Matter Integrity to Recognition Memory Speed: Fixel-Based and Fornix Analyses in Young to Middle Adulthood

The paper examines how white matter micro- and macrostructural properties relate to recognition memory speed across young to middle adulthood using fixel-based analysis and fornix tractography.

Testing retrogenesis and physiological explanations for tract-wise white matter aging: links to developmental order, fibre calibre, and vascularization

The paper investigates whether white matter aging follows developmental order (retrogenesis) or physiological factors like fibre size and perfusion, finding mixed support for both theories.

White matter reorganization of motor and affective-motivational networks in pain-indifferent carriers of the R221W mutation

The paper identifies structural and functional white matter changes in R221W mutation carriers, suggesting motor under-reactivity rather than sensory insensitivity in congenital insensitivity to pain.

Integration of steady-state diffusion MRI with Neural Posterior Estimation (NPE) for post-mortem investigations

This paper integrates DW-SSFP diffusion MRI with neural posterior estimation to improve parameter estimation in post-mortem tissue.

Cortical and white matter myelination proceed in concert during early infancy

This study shows that gray and white matter myelination are synchronized in early infancy, with synchrony linked to gestational age and motor outcomes.

Unveiling genetic architecture of white matter microstructure through unsupervised deep representation learning of fractional anisotropy images

This paper introduces a deep learning framework to analyze fractional anisotropy images, identifying genetic variants associated with white matter microstructure and linking them to neurological disorders.

Cardiac diffusion kurtosis imaging in the human heart in vivo using 300mT/m gradients

This paper demonstrates the feasibility of cardiac diffusion kurtosis imaging (DKI) in humans using high gradient strength MRI, showing non-Gaussian water diffusion behavior and significant radial kurtosis differences.

Detection of Region-specific Fiber Damage within Injured Spinal Cord Using Advanced Diffusion MRI

This study uses diffusion MRI techniques to detect region-specific fiber damage in spinal cord injury, finding that fractional anisotropy and axonal volume fraction are most effective biomarkers.

White matter geometry confounds Diffusion Tensor Imaging Along Perivascular Space (DTI-ALPS) measures

Radial diffusivity asymmetry driving DTI-ALPS indices pervades white matter, persists at high b-values, and tracks crossing fibers, axonal undulation and dispersion rather than perivascular diffusion.

Neurite density but not myelination of specific fiber tracts links polygenic scores to general intelligence

The paper investigates how polygenic scores for intelligence relate to general intelligence through white matter microstructural properties, finding that neurite density mediates this relationship.

A Novel Registration Framework for Aligning Longitudinal Infant Brain Tensor Images

This paper introduces a groupwise registration framework for longitudinal infant DTI images, improving alignment accuracy through clustering and sample-specific common space alignment.

In Vivo Tensor-Valued Diffusion MRI Reveals Isotropic-Anisotropic Kurtosis Mismatch in a Rat MCAO Stroke Model

The paper introduces an anisotropic-isotropic kurtosis mismatch framework using tensor-valued diffusion MRI to characterize stroke lesions in a rat model, finding significant mismatches in key metrics that correlate with pathological findings.

Assessing changes in whole-brain structural connectivity in the unilateral 6-hydroxydopamine rat model of Parkinson's Disease using diffusion imaging and tractography

This study uses diffusion imaging and tractography to analyze structural connectivity changes in a rat model of Parkinson's Disease, identifying lesion-specific and compensatory neural networks.

Big Data, Small Bias: Harmonizing Diffusion MRI-Based Structural Connectomes to Mitigate Site-Related Bias in Data Integration

This paper develops a harmonization framework for structural connectomes to reduce site-related biases, showing that gamma-GLM improves generalizability and statistical power in multi-site analyses.

Harmonization of Structural Brain Connectivity through Distribution Matching

This paper introduces a distribution-matching method to harmonize structural brain connectivity across sites and scanners, showing competitive performance compared to existing methods.

Diffusion Basis Spectrum Imaging of White Matter in Schizophrenia and Bipolar Disorder

This study uses DBSI to find increased neuroinflammation and decreased axonal density in schizophrenia compared to controls and bipolar disorder.

Unbiased Population-Based Statistics to Obtain Pathologic Burden of Injury after Experimental TBI

The paper introduces an unbiased whole-brain analysis method to quantify injury burden after traumatic brain injury, showing it is statistically robust and captures longitudinal changes without preselected ROIs.

Mapping caudolenticular gray matter bridges in the human brain striatum through diffusion magnetic resonance imaging and tractography

This study introduces a novel tractography method to reconstruct and analyze caudolenticular gray matter bridges in the human brain using diffusion MRI, demonstrating their microstructural properties.

Coupled aging of cyto- and myeloarchitectonic atlas-informed gray and white matter structural properties

The paper examines age-related changes in gray and white matter structural properties using a longitudinal design and histology-informed parcellation, finding coupled aging gradients in specific brain regions.

Mapping grey and white matter activity in the human brain with isotropic ADC-fMRI

This study introduces isotropic ADC-fMRI to detect grey and white matter activity, showing it is more temporally specific than BOLD-fMRI and provides balanced mapping of both brain regions.

MegaTrack: a framework for the anatomically accurate and time-efficient virtual dissection and analysis of large-scale tractography datasets

MegaTrack provides a framework for efficient and anatomically accurate analysis of large-scale tractography datasets, enabling rapid dissection and metric extraction with high reproducibility and reduced processing time.

The relationship of white matter tract orientation to vascular geometry in the human brain

This study compares the orientation of white matter nerve fibers and vasculature in the human brain using diffusion MRI and susceptibility weighted imaging, finding that vasculature aligns with some but not all white matter tracts.

Mapping Early Brain Maturation: Anatomical Substrates of Cortical Connectivity Shifts in Neonates

This study maps cortical connectivity shifts in neonates using diffusion MRI, identifying age-dependent changes and their implications for brain development and disorders.

Cross-site harmonization of diffusion MRI data without matched training subjects

This paper introduces RISH-GLM, a method to harmonize diffusion MRI data across sites without requiring matched training subjects, showing effectiveness with unmatched groups and multiple sites.

Enhanced Structural Brain Connectivity Analyses Using High Diffusion-weighting Strengths

This study shows that higher diffusion-weighting strengths (b-values) improve connectome reconstruction accuracy by reducing fiber orientation uncertainty, but SNR loss limits benefits beyond b=6000 s/mm2.

A unified imaging-histology framework for superficial white matter architecture studies in the human brain

The paper develops a computational framework to study superficial white matter organization using 3D histology and 7T MRI, finding high structural complexity in the first 2 mm below the cortical boundary and correlations with cortical geometry and connectivity.

Lifespan reference curves for harmonizing multi-site regional brain white matter metrics from diffusion MRI

The paper creates lifespan reference curves for white matter microstructure using diffusion MRI data from multiple datasets and validates them with ApoE4 risk factor analysis.