Tryptophan and brain disorders

Maternal immune activation during pregnancy alters early neurobehavioral development in nonhuman primate offspring

This study examines the effects of maternal immune activation on neurobehavioral development in rhesus monkey offspring, finding reduced gray matter volume in specific brain regions.

The antidepressant effects of asperosaponin VI are mediated by the suppression of microglial activation and reduction of TLR4/NF-kB induced IDO expression

This study shows that asperosaponin VI reduces depressive-like behaviors in LPS-treated mice by suppressing microglial activation and the TLR4/NF-κB-induced IDO pathway.

Disentangling causal relationships between inflammatory markers and depression: a bidirectional Mendelian randomization analysis

This study uses bidirectional Mendelian randomization to investigate causal relationships between inflammatory markers and depression, finding a causal effect of IL-6 on major depressive disorder.

Enhancing rigor and reproducibility in maternal immune activation models: practical considerations and predicting resilience and susceptibility using baseline immune responsiveness before pregnancy

This study identifies variability factors in maternal immune activation models and shows baseline immune responsiveness predicts offspring outcomes.

Unique Neurophysiological Vulnerability of Visual Attention Networks to Acute Inflammation

This study shows that acute mild inflammation from typhoid vaccination alters neurophysiological processes related to attention, specifically increasing alpha suppression in alerting without affecting behavior.

Preliminary evidence that maternal immune activation specifically increases diagonal domain volume in the rat brain during early postnatal development

This study shows that maternal immune activation increases the volume of the diagonal domain in rat brains during early postnatal development, with potential sex differences.

Maternal immune activation causes age-specific changes in cytokine receptor expression in offspring throughout development

This study shows maternal immune activation causes age-specific changes in cytokine receptor expression in offspring's frontal cortex, with potential implications for neuropsychiatric disorders.

Supervised machine learning to decipher the complex associations between neuro-immune biomarkers and quality of life in schizophrenia

This study uses machine learning to identify predictors of health-related quality of life in schizophrenia, finding that neuro-immune biomarkers and cognitive impairments significantly impact HR-QoL.

A new schizophrenia model: immune activation is associated with induction of thetryptophan catabolite pathway and increased eotaxin levels which together determinememory impairments and schizophrenia symptom dimensions.

This paper investigates how immune activation and tryptophan catabolite pathway activity contribute to memory impairments and schizophrenia symptom dimensions.

Assessing 42 inflammatory markers in 321 control subjects and 887 major depressive disorder cases: BMI and other confounders and overall predictive ability for current depression

The paper evaluates 42 inflammatory markers in MDD cases and controls, finding strong confounding effects and limited predictive power of individual markers for MDD diagnosis.

Treatment-resistant depression and peripheral C-reactive protein

This study finds elevated peripheral C-reactive protein (CRP) is associated with treatment-resistant depression, childhood adversity, and specific depressive and anxious symptoms.

On the transdiagnostic nature of peripheral biomarkers in major psychiatric disorders: a systematic review

This paper reviews peripheral biomarkers in major psychiatric disorders, finding that five molecules show similar variation across disorders, suggesting transdiagnostic systemic consequences rather than specific diagnostic markers.