Invertebrate Immune Response Mechanisms

Microbiome-Derived RNA Promotes Heritable Defense Against Intracellular Pathogens in Caenorhabditis elegans

The paper identifies a microbiome-derived RNA that primes C. elegans immunity against intracellular pathogens and confers heritable protection.

Live Imaging of Epithelial Phagocyte Differentiation in the Drosophila Ovary RevealsTransient and Novel Behaviors

The paper uses live imaging to study epithelial cell transformation into phagocytes in Drosophila ovaries, revealing new transient behaviors in phagocytic processes.

Non-Additive Transcriptional Regulation Underpins Additive Survival Trait In Populations Of Drosophila Selected For Increased Post Infection Survival

The paper investigates the genetic and transcriptional basis of post-infection survival in Drosophila selected for increased survival, finding additive genetics but sex-specific transcriptional regulation and functional bottlenecks.

Photoperiod induces sex-specific immune priming in Pyrrhocoris apterus

This study shows that photoperiod induces sex-specific immune priming in linden bugs, with short-day conditions enhancing immune activity in females but not males.

Activation of Toll and IMD pathways in the Drosophila brain following local and systemic bacterial infection

This study shows that bacterial brain infection in Drosophila activates Toll and IMD immune pathways in the brain, with glia as the primary responders, and that these responses persist even after bacterial clearance.

Single-type neuron transcriptomics uncovers cell-type-specific regulators of host defense in Caenorhabditis elegans

The paper identifies cell-type-specific regulators of host defense in C. elegans neurons using single-type neuron transcriptomics, revealing genes critical for immune response that are missed in bulk RNA-seq.

Persistent viral infection in the Drosophila fat body is associated with immune activation at the single-cell level

The paper examines transcriptional changes in Drosophila fat body cells during persistent viral infections using snRNA-seq data, revealing immune pathway activation and transposable element dysregulation.

PGRP-LA regulates peritrophic matrix synthesis and influences trypanosome infection outcomes in tsetse flies

This study identifies PGRP-LA as a regulator of peritrophic matrix integrity in tsetse flies, influencing trypanosome infection outcomes by modulating gut barrier function rather than canonical immune signaling.

Functional characterization of specialized immune cells in a cnidarian reveals an ancestral antiviral program

The paper identifies a novel antiviral immune cell type in cnidarians by analyzing gene expression and function in Nematostella vectensis embryos.

Targeted degradation of Drosophila FOG homolog U-shaped mimics macrophage transdifferentiation in S2 cells

The paper shows that degrading U-shaped in Drosophila S2 cells reprograms them to a lamellocyte-like state, mimicking macrophage transdifferentiation.

Microbiota-induced fatty acid synthesis facilitates intestinal infection and immune-mediated damage in Drosophila

This study shows that gut microbiota, specifically Lactiplantibacillus plantarum, enhances fatty acid synthesis in Drosophila, promoting pathogen virulence and immune-mediated damage.

The tobacco hornworm as a novel host for the study of bacterial virulence

This study evaluates the tobacco hornworm as a model for bacterial virulence, showing dose-dependent mortality, secreted product effects, and dynamic bacterial distribution in infected larvae.

Mitochondrial metabolic remodeling drives innate immune activation in Drosophila hemocytes

This study shows that mitochondrial metabolic reprogramming is essential for innate immune activation in Drosophila hemocytes, linking mitochondrial dynamics to immune responses.

UVB-Induced Genotoxic Stress Activates the DNA Damage Response and Innate Immune Pathways in Sea Urchin Coelomocytes

This study shows that UVB-induced DNA damage activates DDR and innate immune pathways in sea urchin coelomocytes, revealing conserved mechanisms linking DDR with immunity in invertebrates.

Tumor-induced species-specific dysbiosis drives renal innate immunity and nephrogenic ascites

This study shows tumors induce species-specific microbiome changes that trigger renal inflammation and ascites in Drosophila.

HSC71 acetylation confers protection against Spiroplasma eriocheiris infection by inhibiting apoptosis and promoting ROS production in arthropods

This study shows that acetylation of HSC71 by Crat protects arthropods from Spiroplasma eriocheiris infection by reducing apoptosis and increasing ROS production.

Sex Bias in Iron Sequestration by Transferrin 1 Modulates Sexually-Dimorphic Infection Outcomes in Drosophila melanogaster

This study shows that sex differences in iron sequestration via Transferrin 1 affect infection outcomes in Drosophila, with males being more resistant to Providencia alcalifaciens.

The macroecology of immunity: predominant influence of climate on invertebrate immune response

This study investigates the factors shaping immune response variation in odonates across two biomes, finding that climate, particularly precipitation, has the strongest influence.

Cell-specific responses of Anopheles gambiae fat body to blood feeding and infection at a single nuclei resolution

The paper characterizes the cellular diversity and functional responses of Anopheles gambiae fat body cells to blood feeding and infection at single-cell resolution, identifying specialized roles in immunity and reproduction.

Tachykinin-related peptide signalling is important for the immune response of the mealworm beetle Tenebrio molitor L.

This study investigates the role of tachykinin-related peptide (TRP) signaling in the immune response of Tenebrio molitor, showing that TRP and TRPR genes are downregulated during immune activation and that TRPs modulate antimicrobial peptide expression and phenoloxidase activity.

Spatial microenvironments tune immune response dynamics in the Drosophila larval fat body

The paper investigates spatial patterns of antimicrobial peptide expression in Drosophila larval fat body, finding that these patterns are predetermined and correlate with fluid flow.

Transcriptomic analysis of non-model Drosophilidae reveals novel AMP candidates

The paper analyzes immune responses in three non-model Drosophilidae species to identify novel antimicrobial peptide candidates and assess immune gene variation.

S-nitrosylation of the CLIP-protease, Persephone, Regulates Drosophila innate immunity

This study identifies Gsnor's role in regulating S-nitrosylation of Persephone, a Toll pathway protease, to modulate innate immunity in Drosophila.

Loss of immune signalling pathways and increased pathogen susceptibility associated to photosymbiosis in acoels

This study shows that acoels lack conserved immune genes, leading to increased pathogen susceptibility in photosymbiotic species.

Cold-Shock-Mediated Inhibition of Silk Extrusion in Galleria mellonella (Lepidoptera: Pyralidae) for Improved Handling in Infection Studies: Effects on Developmental Traits and Pathogen Susceptibility

This paper introduces a cold-shock method to inhibit silk extrusion in Galleria mellonella larvae, improving handling for infection studies without compromising viability.

Single-cell RNA analysis reveals unexpected hemocyte plasticity and immune cell specialization in a Drosophila overgrowth model

The paper uses single-cell RNA sequencing to analyze hemocyte diversity in Drosophila overgrowth models, identifying new plasmatocyte subtypes and plasticity under chronic apoptotic signaling.

IbinA and IbinB regulate the Toll pathway-mediated immune response in Drosophila melanogaster

This study identifies IbinA and IbinB as regulators of the Toll pathway-mediated immune response in Drosophila, showing distinct roles in infection susceptibility and tissue protection.

Distinct Bomanins at the Drosophila 55C locus function in resistance and resilience to infections

The paper investigates the roles of distinct Bomanin peptides from the 55C locus in Drosophila resistance and resilience to infections, finding overlapping and specific functions against different pathogens.

Clodronate liposomes untangle the role of hemocytes in Apis mellifera response to temperature variation and microbial infection

This study uses clodronate liposomes to deplete hemocytes in honey bees, revealing age- and temperature-dependent effects on immune response and survival to bacterial infections.

The study of the Drosophila innubila Nudivirus in cells and flies

This paper develops a DiNV model system for studying DNA virus-host interactions in Drosophila by creating cell lines, assays, and infection protocols.